Press Release Details
Twist Bioscience Showcases Next-Generation Sequencing Presentations at Virtual American Society for Human Genetics 2020 Annual Meeting
-- Presentations Detail Twist’s Methylation Solution, a Cost-Effective Alternative to Single Nucleotide Polymorphism (SNP) Microarray Technology and Data on the Infectious Disease Product Line --
“The data presented at ASHG highlight the diverse applications of our NGS target enrichment technology which can be applied to consumer genomics, cancer detection, rare disease research, as well as tracking viral evolution of infectious diseases,” said Emily M. Leproust, Ph.D., CEO and co-founder of
In addition to customer presentations from
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Poster #3568: Targeted Sequencing-based Genotyping as a Competitive Alternative to Genotyping Arrays. In this poster, a case study showcasing the design of a
Twist Custom Target Capture Panel for the identification of hundreds of thousands of markers by NGS. In this groundbreaking poster, data demonstrate that Twist can apply itsCustom Panel design algorithms to generate an exceptionally large target enrichment panel with more than 240,000 single nucleotide polymorphism (SNP) with exceptional and consistent performance. These data show that Twist is able to produce a unified workflow to merge genotyping with exome sequencing, leading to considerable cost savings while maintaining high-quality data. - Poster #2445: Tunability and Optimization Using the Twist Fast Hybridization Target Enrichment System for DNA Methylation Sequencing. This poster highlights Twist’s Targeted Methylation Sequencing Solution and a novel and innovative way to generate libraries used for methylation detection. While genetic sequencing has allowed the ability to link sequence with a number of disease states, other factors, including DNA methylation modifications on adenines and cytosines, can affect gene expression through epigenetic processes. Twist’s solution can be used in combination with several different sized custom designed DNA methylation panels and tuned to best fit timelines and preferred final picard metrics while differentiating original methylation states.
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Poster #3293: A Target Enrichment Approach for Identifying Infectious Disease. In this poster, we demonstrate Twist's target enrichment systems as a sensitive and informative approach combining library preparation and 30 minute Fast Hybridization for detecting viral agents that can be RNA or DNA as well as single- or double-stranded. The data show that our
SARS-CoV-2 Research Panel can detect the virus with as few as 10 copies of SARS-CoV-2 genome. Extending our results beyond single infections, the data demonstrate that Twist’sRespiratory Virus Research Panel simultaneously detects multiple viral agents which can then be sequenced with excellent coverage in a model of co-infection.
The posters will be available through the resources section of the
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This press release contains forward-looking statements. All statements other than statements of historical facts contained herein are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements involve known and unknown risks, uncertainties, and other important factors that may cause Twist Bioscience’s actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the risks and uncertainties of the ability to attract new customers and retain and grow sales from existing customers; risks and uncertainties of rapidly changing technologies and extensive competition in synthetic biology could make the products
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