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Goodwill and Intangible Assets - Goodwill Balance (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
Goodwill [Roll Forward]
Balance at beginning of year	$ 85,811	$ 85,811
Sale of business (see note 6)	(3,616)	0
Balance at end of year	$ 82,195	$ 85,811

- Definition

Amount, after accumulated impairment loss, of asset representing future economic benefit arising from other asset acquired in business combination or from joint venture formation or both, that is not individually identified and separately recognized.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 55
-Paragraph 24
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482548/350-20-55-24

Reference 2: http://www.xbrl.org/2003/role/exampleRef
-Topic 805
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Reference 3: http://www.xbrl.org/2003/role/exampleRef
-Topic 805
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Reference 4: http://www.xbrl.org/2003/role/exampleRef
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Reference 5: http://www.xbrl.org/2003/role/exampleRef
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Reference 6: http://www.xbrl.org/2003/role/exampleRef
-Topic 280
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-Section 55
-Paragraph 49
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482785/280-10-55-49

Reference 7: http://www.xbrl.org/2003/role/exampleRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 100
-Subparagraph (d)
-Publisher FASB
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Reference 8: http://www.xbrl.org/2003/role/exampleRef
-Topic 852
-SubTopic 10
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-Section 55
-Paragraph 10
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481372/852-10-55-10

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 210
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(15))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 45
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-URI https://asc.fasb.org/1943274/2147482598/350-20-45-1

Reference 11: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
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-URI https://asc.fasb.org/1943274/2147482573/350-20-50-1

Reference 12: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
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-Paragraph 1
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482573/350-20-50-1

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 942
-SubTopic 210
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-03(10)(1))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478546/942-210-S99-1

Reference 14: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 805
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 4
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479581/805-30-50-4

+ Details

Subsequent Events	12 Months Ended
Subsequent Events	Sep. 30, 2025
Subsequent Events [Abstract]
Subsequent Events	Subsequent Events On November 13, 2025, the Company entered into an amendment to a lease agreement for the Company's premises in South San Francisco, California, in order to consolidate other offices in South San Francisco into a single location. This amendment increases the leased premises by approximately 33,000 square feet ("Additional Premises") and extends the termination date of the lease until June 30, 2036. In accordance with the amended lease agreement, the monthly base rent for the entire premises is approximately $0.5 million at commencement and includes provisions for rent increases by 3% annually and provides for base rent abatement with respect to the original premises for 15 months and base rent abatement with respect to the Additional Premises for 12 months. The Company is also responsible for utilities, maintenance, insurance, and property taxes. The landlord will provide the Company with a tenant improvement allowance in connection with the Company’s improvements to the premises of approximately $24.4 million. The amendment also gives the Company the right, on or before December 31, 2026, to elect to expand the premises to include additional space in the building of approximately 33,000 square feet. * * * * *

Summary of Significant Accounting Policies

12 Months Ended

Sep. 30, 2025

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

Basis of Presentation

The consolidated financial statements, which include the Company’s accounts and the accounts of its wholly-owned subsidiaries, are prepared in accordance with U.S. generally accepted accounting principles (or “GAAP”). All intercompany balances and accounts are eliminated in consolidation.

To conform with current fiscal year 2025 presentation, the Company reclassified $1.5 million of investment in equity securities included within other non-current assets to investment in equity securities in the consolidated balance sheet as of September 30, 2024.

Use of Estimates

The presentation of consolidated financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the consolidated financial statements and the reported amounts of revenue and expenses during the reporting period. Such estimates include the valuation of deferred tax assets, stock-based compensation expense, transaction price and progress toward completion of performance obligation under the contracts with customers, determination of the net realizable value of inventory, useful life of developed technology, valuation assumptions used in the calculation of the impairment of long-lived assets, restructuring costs and incremental borrowing rate for operating leases. Actual results could differ from those estimates.

Concentration of Credit Risk

Financial instruments that potentially subject the Company to a concentration of credit risk consist of cash and cash equivalents, short-term investments and accounts receivable. Substantially all of the Company’s cash and

cash equivalents, short-term investments are held with two financial institutions that management believe are of high credit quality. Such deposits may, at times, exceed federally insured limits. The Company’s investment policy addresses the level of credit exposure by establishing a minimum allowable credit rating and by limiting the concentration in any one investment.

The Company’s accounts receivable is derived from customers located principally in the United States, Europe and Asia-Pacific region ("APAC"). The Company performs ongoing credit evaluations of its customers and maintains allowances for potential credit losses on customers’ accounts when deemed necessary. The Company does not typically require collateral from its customers. Credit losses historically have not been material. See Note 3, Revenues, for more information for customer concentration.

Cash and Cash Equivalents and Restricted Cash

Cash equivalents that are readily convertible to cash are stated at cost, which approximates fair value. The Company considers all highly liquid investments with an original or remaining maturity of three months or less at the time of purchase to be cash equivalents. Cash equivalents consist of investments in money market funds as of September 30, 2025 and 2024.

Restricted cash represents cash held at financial institutions that are pledged as collateral for stand-by letters of credit for lease commitments. The lease related letters of credit will lapse at the end of the respective lease terms through 2044.


	September 30,
(in thousands)	2025		2024
Cash and cash equivalents	$	183,049	$	226,316
Restricted cash, non-current	2,376		2,816
Total cash, cash equivalents and restricted cash	$	185,425	$	229,132

Short-term Investments

The Company invests in various types of securities, including United States government, commercial paper, and corporate debt securities. The Company classifies its investments as available-for-sale and records them at fair value based upon market prices at period end.

The Company regularly reviews its short-term investments to identify and evaluate investments that have indications of possible impairment from credit losses or other factors. For available-for-sale debt securities in an unrealized loss position, the Company evaluates whether a current expected credit loss exists based on available information relevant to the credit rating of the security, current economic conditions and supportable forecasts. The allowance for credit loss is recorded in other income (expense), net, on the consolidated statements of operations and comprehensive loss, not to exceed the amount of the unrealized loss. Any excess unrealized loss other than the credit loss is recognized in accumulated other comprehensive income or loss in the stockholders' equity section of the consolidated balance sheets. The Company made an accounting policy election to not measure an allowance for credit losses for accrued interest receivable. The accrued interest balance as of September 30, 2025 and 2024 was $1.2 million and $1.1 million. There was no allowance for credit losses relating to the short-term investments recognized as of September 30, 2025.

The cost of securities sold is based on the specific identification method and realized gains and losses are included in other income (expense), net. Dividend and interest income are recognized when earned. The Company may sell these securities at any time for use in current operations.

Accounts Receivable and Allowance for Credit Losses

Accounts receivables include amounts billed and currently due from customers, recorded at the net invoice value and are not interest bearing. The Company has a short order-to-invoice lifecycle, as most products can be manufactured within one month. Upon delivery of the products to the customer, the Company invoices the customer. The typical timing of payment is net 30 days. If the right to payment for services performed was conditional on something other than the passage of time, the unbilled amount would be recorded as a separate contract asset.

The Company is exposed to credit losses primarily through accounts receivable from sales of its products and services. The Company maintains an allowance for credit losses for expected uncollectible accounts receivable and contract assets, which is recorded as an offset to accounts receivable or contract assets and provisions for credit losses are recorded in selling, general and administrative expense in the consolidated statements of operations and comprehensive loss.

The allowance for current expected credit losses is based on a review of customer accounts and considers historical credit loss information that is adjusted for current economic and business conditions and anticipated future economic events that may impact collectability. In developing its expected credit loss estimate, the Company evaluated the appropriate grouping of accounts receivable and contract assets based upon its evaluation of risk characteristics, including consideration of region and industries of the customers. Specific allowance amounts are established to record the appropriate provision for customers that have a higher probability of default. The allowance for credit losses is reviewed on a regular basis to assess the adequacy of the allowance and once a receivable is deemed to be uncollectible, such balance is charged against the allowance.

Fair Value of Financial Instruments

The Company applies fair value accounting for all financial and non-financial assets and liabilities that are recognized or disclosed at fair value in the financial statements on a recurring basis. The Company defines fair value as the price that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. When determining the fair value measurements for assets and liabilities which are required to be recorded at fair value, we consider the principal or most advantageous market in which we would transact and the market-based risk measurements or assumptions that market participants would use in pricing the asset or liability, such as risks inherent in valuation techniques, transfer restrictions and credit risks. See Note 5, Fair value measurements, for more information. The carrying amounts of the Company’s financial instruments including cash equivalents, short term investments, and accounts receivable approximate fair value due to their relatively short maturities.

Inventories

Inventories are stated at the lower of cost or net realizable value. Cost is computed using standard cost which approximates actual cost on a first-in, first-out basis. The Company periodically reviews its inventories to identify obsolete, slow-moving, excess or otherwise unsaleable items. If obsolete, slow-moving, excess or unsaleable items are observed and there are no alternate uses for the inventory, the Company records a write-down to net realizable value through a charge to cost of revenues on our consolidated statements of operations and comprehensive loss. The determination of net realizable value requires judgment, including consideration of many factors, such as estimates of future product demand, past experience, product net selling prices, current and future market conditions, the age and nature of inventories, and potential product obsolescence, among others.

Property and Equipment

Property and equipment are stated at cost less accumulated depreciation and amortization. Depreciation and amortization are computed using the straight-line method over the estimated useful lives of the assets or the lesser of the useful life and the remaining lease term of the respective leasehold improvements assets, if any. Upon retirement or sale, the cost of assets disposed of and the related accumulated depreciation are eliminated from the accounts and any resulting gain or loss is credited or charged to operations in the period recognized. Repairs and maintenance costs are expensed as incurred.

Estimated lives of property and equipment are as follows:


Laboratory equipment			5 Years
Furniture, fixtures and other equipment			5 Years
Computer equipment			3 Years
Vehicles			5 Years
Computer software			3 Years
Leasehold improvements			Lesser of useful life or lease term

Capitalized Software Held for Internal Use

Costs associated with internal-use software systems during the application development stage are capitalized. Capitalization of costs begins when the preliminary project stage is completed, management has committed to funding the project, and it is probable that the project will be completed and the software will be used to perform the function intended. Costs include external direct costs of services and applicable personnel costs of employees devoted to specific software application development. Personnel costs consist of salaries, employee benefit costs, bonuses and stock-based compensation expense. The capitalized amounts are included in property and equipment, net on the consolidated balance sheets.

Capitalization ceases at the point when the project is substantially complete and is ready for its intended purpose. Capitalized costs are amortized from the project completion date, using the straight-line method over an estimated useful life of the assets.

Finite-lived Intangible Assets

Finite-lived intangible assets are recorded at cost, net of accumulated amortization, and, if applicable, impairment charges. Amortization of finite-lived intangible assets is recorded over the assets’ estimated useful lives on a straight-line basis or based on the pattern in which economic benefits are consumed, if reliably determinable. The Company reviews the finite-lived intangible assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. See “Impairment of long-lived assets” for additional information.

Impairment of Long-lived Assets

The Company's long-lived assets consists of property and equipment, right of use assets and finite-lived intangible assets. The Company evaluates long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. If indicators of impairment are present, the Company tests for recoverability by comparing the estimated undiscounted future cash flows expected to result from the use of the asset over its remaining useful life to the carrying amount of the asset or asset group. If the asset or asset group is determined to be impaired, any excess of the carrying value of the asset or asset group over its estimated fair value is recognized as an impairment loss. Impairment assessments inherently involve judgment as to assumptions about expected future cash flows and the impact of market conditions on those assumptions. See Note 18, Impairment of long-lived assets for the additional information and disclosures related to impairment of long-lived assets.

Leases

The Company determines if an arrangement is or contains a lease at inception and classifies each lease as operating or financing. Operating lease right-of-use assets represent the Company’s right to use an underlying asset for the lease term and lease liabilities represent the Company’s obligation to make lease payments made during the lease term, net of any tenant improvement allowance. Operating lease right-of-use assets and liabilities are recognized at the lease commencement date based on the present value of lease payments over the lease term. In determining the present value of committed lease payments, the Company uses its incremental borrowing rate based on the information available at the lease commencement date which includes significant assumptions made including the Company’s estimated credit rating, annual percentage yields from corporate debt financings of companies of similar size and credit rating over a loan term approximating the remaining term of each lease, and government bond yields for terms approximating the remaining term of each lease in countries where the leased assets are located. Certain leases include payments of operating expenses that are dependent on the landlord’s estimate, and these variable payments are therefore excluded from the lease payments used to determine the operating lease right-of-use asset and lease liability. Lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise any such options. Operating lease right-of-use assets are adjusted for prepaid lease payments, lease incentives and initial direct costs incurred. Lease expense is recognized on a straight-line basis over the expected lease term.

The Company elected to not apply the recognition requirements of Topic 842 to short-term leases with terms of 12 months or less which do not include an option to purchase the underlying asset that the Company is reasonably certain to exercise. For short-term leases, lease payments are recognized as operating expenses on a straight-line basis over the lease term. The Company elected to account for lease and non-lease components as a single lease component.

Additional information and disclosures required by Topic 842 are contained in Note 9, Leases.

Goodwill

The company assesses goodwill for impairment at the reporting unit level annually and whenever events occur or circumstances change that would more likely than not reduce the fair value of a reporting unit below its carrying amount. Such events or circumstances generally include the occurrence of operating losses or a significant decline in earnings associated with one or more of the company’s reporting units. The company is permitted to first assess qualitative factors to determine whether the quantitative goodwill impairment test is necessary. If the qualitative assessment results in a determination that the fair value of a reporting unit is more likely than not less than its carrying amount, the company performs a quantitative goodwill impairment test. The company may bypass the qualitative assessment for the reporting unit in any period and proceed directly to the quantitative goodwill impairment test. The company estimates the fair value of its reporting unit by using forecasts of discounted future cash flows and peer market multiples. The company would record an impairment charge based on the excess of a reporting unit’s carrying amount over its fair value (limited to the amount of goodwill). For 2025 and 2024, the Company elected to proceed directly to the step-one assessment which indicated that the fair value of its single reporting unit substantially exceeded the carrying value.

Segment Information

The Company is a synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology and manufactures synthetic genes, tools for next-generation sequencing preparation, and antibody libraries for drug discovery and development and operates as one reportable and operating segment. The Company’s chief operating decision-maker, its Chief Executive Officer (CEO), reviews the Company’s operating results on an aggregate basis for purposes of allocating resources and evaluating financial performance.

Foreign Currency Transactions and Translation

The Company's consolidated financial statements are presented in U.S. dollars. The functional currency for certain foreign subsidiaries is their local currency. Revenues, expenses, gains and losses for non-U.S. dollar functional currency entities are translated into U.S. dollars using average currency exchange rates for the period. Assets and liabilities for such entities are translated using exchange rates that approximate the rate at the balance sheet date. Foreign currency translation adjustments are recorded as a component of accumulated other comprehensive loss on the Company's consolidated balance sheets. Foreign currency transaction gains and losses on transactions not denominated in functional currency are recorded in Other income (expense), net, on the consolidated statements of operations.

Revenue Recognition

The Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the Company expects to receive in exchange for those goods or services. To determine revenue recognition for contracts with customers, the Company performs the following five steps:

i.identification of the promised goods or services in the contract;

ii.determination of whether the promised goods or services are performance obligations including whether they are distinct in the context of the contract;

iii.measurement of the transaction price, including the constraint on variable consideration;

iv.allocation of the transaction price to the performance obligations based on estimated selling prices; and

v.recognition of revenue when (or as) the Company satisfies each performance obligation. A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account.

See Note 3, Revenue recognition, for detailed discussions of revenue recognition, and how the five steps described above are applied.

Cost of Revenue

Cost of revenues primarily consists of cost incurred in the production and delivery of the Company's products and consists of production materials, personnel costs, cost of expensed equipment and consumables, laboratory supplies, consulting costs, depreciation, production overhead costs, information technology, maintenance and facility costs. Personnel costs consist of salaries, employee benefit costs, bonuses, and stock-based compensation expense. In addition, cost of revenue includes royalty costs for licensed technologies included in the Company’s products, and provisions for slow-moving and obsolete inventory.

Research and Development

Research and development expenses consist of compensation costs, employee benefits, subcontractors, research supplies, allocated facility related expenses and allocated depreciation and amortization. All research and development costs are expensed as incurred.

Advertising Costs

Costs related to advertising and promotions are expensed to sales and marketing as incurred. Advertising and promotion expenses for the years ended September 30, 2025, 2024 and 2023, were $7.0 million, $5.2 million and $2.9 million, respectively.

Stock-based Compensation

The Company maintains performance incentive plans under which incentive and nonqualified stock options, performance-based stock options, restricted stock units, performance-based stock units and through employer purchase plan are granted primarily to employees and may be granted to members of the board of directors and certain non-employee consultants, and employees may participate in an employee stock purchase plan.

The Company recognizes stock compensation in accordance with the Accounting Standard Codification ("ASC") 718, Compensation—Stock Compensation. ASC 718 requires the recognition of compensation expense, using a fair value-based method, for costs related to all stock-based payments including stock options, restricted stock units and employee stock purchase plan.

The Company recognizes fair value of stock options granted to employees and non-employees as a stock-based compensation expense over the period in which the related services are received. The Company recognizes forfeitures as they occur. The Company believes that the estimated fair value of stock options is more readily measurable than the fair value of the services rendered.

For performance-based awards, expense is recognized over the period from the grant date to the estimated attainment date, which is the derived service period of the award, if management determines that it is probable that the performance-based vesting conditions will be achieved.

Net Loss Per Share Attributable to Common Stockholders

The Company calculates its basic and diluted net loss per share attributable to common stockholders in conformity with the two-class method required for companies with participating securities. In computing diluted net loss attributable to common stockholders, undistributed earnings are re-allocated to reflect the potential impact of dilutive securities. For purposes of the calculation of diluted net loss per share attributable to common stockholders, unvested shares of common stock issued upon the early exercise of stock options, shares issuable for employee stock purchase plan contributions received, warrants to purchase common stock, unvested restricted common stock, unvested restricted stock units and stock options to purchase common stock are considered potentially dilutive securities but have been excluded from the calculation of diluted net loss per share attributable to common stockholders as their effect is antidilutive.

Basic and diluted net loss per share of common stock attributable to common stockholders is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, less shares subject to repurchase, and excludes any dilutive effects of employee stock-based awards and warrants. Because the Company has reported a net loss for the years ended September 30, 2025, 2024 and 2023, diluted net loss per common share is the same as the basic net loss per share for those years.

Income Taxes

The Company uses the asset and liability method of accounting for income taxes, in which deferred tax assets and liabilities are recognized for the future tax consequences attributable to the differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assets and liabilities are measured using the enacted tax rates expected to apply in the years in which those tax assets and liabilities are expected to be realized. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in the period that includes the enactment date. A valuation allowance is established if it is more likely than not that all or a portion of the deferred tax asset will not be realized.

The Company’s tax positions are subject to income tax audits. The Company recognizes the tax benefit of an uncertain tax position only if it is more likely than not that the position is sustainable upon examination by the taxing authority, based on the technical merits. The tax benefit recognized is measured as the largest amount of benefit which is more likely than not (greater than 50% likely) to be realized upon settlement with the taxing authority. The Company recognizes interest accrued and penalties related to unrecognized tax benefits in its tax provision.

The Company calculates the current and deferred income tax provision based on estimates and assumptions that could differ from the actual results reflected in income tax returns filed in subsequent years. Adjustments based on filed income tax returns are recorded when identified. The amount of income tax paid is subject to examination by U.S. and foreign tax authorities. The estimate of the potential outcome of any uncertain tax issue is subject to management’s assessment of the relevant risks, facts and circumstances existing at that time. To the extent the assessment of such tax position changes, the change in estimate is recorded in the period in which the determination is made.

Liability Related to the Sale of Future Revenue

The Company accounts for the proceeds received from the monetization of future milestone and royalty payments from its contracts with certain customers as a debt instrument, which is amortized using the effective interest rate method over the estimated term of the arrangement. The Company recognizes interest expense thereon using the effective rate, which is based on its current estimates of future milestone and royalty payments under its customer contracts to be paid to the counterparty over the term of the arrangement. The Company periodically assesses these future estimated payments to impute interest on the carrying value of the liability. To the extent its estimates of future payments to the counterparty are greater or less than previous estimates or the estimated timing of such payments is materially different than previous estimates, the Company will account for any such changes by adjusting the effective interest rate on a prospective basis, with a corresponding impact to the liability. The assumptions used in determining the expected repayment term of the liability also requires that the Company makes estimates that could impact the classification of the liability, interest recorded on such liability, as well as the period over which such interest will be incurred. For further discussion, please see Note 17, Liability related to the sale of future revenue liability.

Investment in equity securities

The Company determines at the inception of each arrangement whether an investment or other interest is considered a variable interest entity (“VIE”). If the investment or other interest is determined to be a VIE, the Company evaluates whether it is considered the primary beneficiary. The primary beneficiary of a VIE is the party that meets both of the following criteria: (i) has the power to direct the activities that most significantly impact the VIE’s economic performance; and (ii) has the obligation to absorb losses or the right to receive benefits from the VIE. For investments in VIEs in which the Company is considered the primary beneficiary, the assets, liabilities and results of operations of the VIE are included in the Company’s consolidated financial statements.

For investments in common stock or in-substance common stock where the Company has significant influence over the financial and operating policies of the investee are accounted for as equity-method investments.

If the Company's equity investment does not meet the requirements of equity method of accounting, the Company accounts for the investment at fair value and has elected to account for its equity investments without a readily determinable fair value using a measurement alternative. Equity investments without readily determinable fair values are recorded using the measurement alternative of cost less impairment, if any, adjusted for observable price changes in orderly transactions for identical or similar investments of the same issuer. Any impairments or adjustments are recorded in Other (income) expense, net on our consolidated statements of operations and comprehensive income (loss).

Contingent Consideration

The Company elected to account for the contingent consideration receivable under the Contribution Agreement with Atlas as a gain contingency in accordance with ASC 450, Contingencies (Subtopic 450-30). Under this approach, the Company recognizes the contingent consideration receivable in earnings after the contingency is resolved. Accordingly, to determine the initial gain on the sale of business, the Company did not include any amount related to the contingent consideration arrangement as part of the consideration received.

Business Combinations

The Company accounts for business combinations using the acquisition method. Under the acquisition method, the purchase price of the acquisition is allocated to the acquired tangible and identifiable intangible assets and assumed liabilities based on their estimated fair values at the time of the acquisition. This allocation involves a number of assumptions, estimates, and judgments that could materially affect the timing or amounts recognized in the Company’s financial statements. As a result, the Company may record adjustments to the fair values of assets acquired and liabilities assumed within the measurement period (up to one year from the acquisition date) with the corresponding offset to goodwill. The most subjective areas of the acquisition accounting method include determining the fair value of the following:

•identifiable intangible assets, including the valuation methodology, estimates of projected revenues, technology obsolescence, and discount rates, as well as the estimated useful life of the intangible assets;

•contingent consideration; and

•goodwill, as measured as the excess of consideration transferred over the acquisition date fair value of the assets acquired, including the amount assigned to identifiable intangible assets, and the liabilities assumed.

The assumptions and estimates are based upon comparable market data and information obtained from the management of the acquired business.

Goodwill is assigned to reporting units that are expected to benefit from the synergies of the business combination as of the acquisition date.

Identifiable intangible assets with finite lives are amortized over their estimated useful lives in a pattern in which the asset is consumed. Acquisition-related costs, including advisory, legal, accounting, valuation, and other similar costs, are expensed in the periods in which those costs are incurred. The results of operations of acquired businesses are included in the Company’s consolidated financial statements from the acquisition date.

Restructuring and Other Costs

Restructuring and other costs are comprised of employee separation costs and other associated costs primarily related to implementing a plan. Employee separation costs principally consist of one-time termination benefits and contractual termination benefits for severance, other termination benefit costs, and stock-based compensation expense for the acceleration of stock awards.

The Company records restructuring charges based on whether the termination benefits are provided under an on-going benefit arrangement or under a one-time benefit arrangement. The Company accounts for on-going benefit arrangements, such as those documented by employment agreements, in accordance with ASC 712, Nonretirement Postemployment Benefits. Under ASC 712, liabilities for post employment benefits are recorded at the time the obligations are probable of being incurred and can be reasonably estimated. The Company accounts for one-time employment benefit arrangements in accordance with ASC 420 Exit or Disposal Cost Obligations. One-time termination benefits are expensed at the date the entity notifies the employee, unless the employee must provide future service, in which case the benefits are expensed ratably over the future service period. Other associated costs are recognized in the period in which the liability is incurred.

Recent Accounting Pronouncements

New Accounting Guidance Adopted

In November 2023, the FASB issued ASU No. 2023-07 "Segment Reporting (Topic 280)". The amendments in this ASU improve reportable segment disclosure requirements, primarily through enhanced disclosures about significant segment expenses. The amendments in this update are effective for fiscal years beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. The Company adopted this ASU for our fiscal year ended September 30, 2025 and provided required disclosure in Note 16. Segment Information.

New Accounting Guidance Issued but Not Yet Effective

In December 2023, the FASB issued ASU No. 2023-09 "Income Taxes (Topic 740)". The amendments in this ASU require that public business entities on an annual basis (1) disclose specific categories in the rate reconciliation and (2) provide additional information for reconciling items that meet a quantitative threshold. The amendments in this update are effective for annual periods beginning after December 15, 2024. The standard is not expected to have a material impact to the Company's consolidated financial statements.

In November 2024, the FASB issued ASU 2024-03, Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures, which will require additional expense disclosures for all public entities. The amendments require that at each interim and annual reporting period, an entity will disclose certain disaggregated expenses included in each relevant expense caption, as well as the total amount of selling expenses and, in annual periods, an entity’s definition of selling expenses. ASU 2024-03 is effective for fiscal years beginning after December 15, 2026, and interim periods within fiscal years beginning after December 15, 2027, with early adoption permitted. The Company is currently evaluating the incremental disclosures that will be required in its consolidated financial statements.

In September 2025, the FASB issued ASU 2025-06, Intangibles - Goodwill and Other - Internal-Use Software (Subtopic 350-40): Targeted Improvements to the Accounting for Internal-Use Software ("ASU 2025-06"), which became effective and simplifies the capitalization guidance by removing all references to software development project stages so that the guidance is neutral to different software development methods. The standard is effective for all entities for annual periods beginning after December 15, 2027, with early adoption permitted. The Company is currently evaluating the impact of this standard to its consolidated financial statements.

The Company has evaluated other recently issued accounting pronouncements and has concluded that the impact of recently issued standards that are not yet effective will not have a material impact on the Company’s financial position or results of operations upon adoption.

Balance Sheet Components - Narrative (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Property, Plant and Equipment [Line Items]
Accounts receivable, allowance for credit loss	$ 600	$ 700
Depreciation	23,800	27,300
Impairment of long-lived assets	0	44,930	$ 6,785
Capitalized computer software, net	3,200	5,200
Capitalized computer software, amortization	2,900	2,600
United States
Property, Plant and Equipment [Line Items]
Property and equipment	102,300	102,300
Non-US
Property, Plant and Equipment [Line Items]
Property and equipment	$ 0	$ 200

Cover Page - USD ($) $ in Millions	12 Months Ended
Cover Page - USD ($) $ in Millions	Sep. 30, 2025	Nov. 13, 2025	Mar. 31, 2025
Cover [Abstract]
Document Type	10-K
Document Annual Report	true
Document Period End Date	Sep. 30, 2025
Current Fiscal Year End Date	--09-30
Document Transition Report	false
Entity File Number	001-38720
Entity Registrant Name	Twist Bioscience Corporation
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	46-2058888
Entity Address, Address Line One	681 Gateway Blvd
Entity Address, City or Town	South San Francisco
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94080
City Area Code	800
Local Phone Number	719-0671
Title of 12(b) Security	Common Stock
Trading Symbol	TWST
Security Exchange Name	NASDAQ
Entity Well-known Seasoned Issuer	Yes
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
ICFR Auditor Attestation Flag	true
Document Financial Statement Error Correction [Flag]	false
Entity Shell Company	false
Entity Public Float			$ 2,320
Entity Common Stock, Shares Outstanding		61,148,026
Documents Incorporated by Reference	Portions of the Registrant’s definitive proxy statement to be filed in connection with its 2025 Annual Meeting of Stockholders are incorporated by reference into Part III of this Form 10-K.
Amendment Flag	false
Entity Central Index Key	0001581280
Document Fiscal Year Focus	2025
Document Fiscal Period Focus	FY

Subsequent Events (Details) - Subsequent events - South San Francisco, California sqft in Thousands, ft² in Thousands, $ in Millions	Nov. 13, 2025 USD ($) ft² sqft
Subsequent Event [Line Items]
Operating lease area \| ft²	33
Monthly base rent	$ 0.5
Percentage of provisions for rent	3.00%
Operating lease term	15 months
Term of additional premises	12 months
Tenant improvement allowance	$ 24.4
Area elected to expand \| sqft	33

Stock-based Compensation (Tables)

12 Months Ended

Sep. 30, 2025

Share-Based Payment Arrangement [Abstract]

Summary of Stock-Based Compensation Expenses

Total stock-based compensation expense recognized were as follows:


	Year ended September 30,
(in thousands)	2025		2024		2023
Cost of revenues	$	6,985	$	4,012	$	4,562
Research and development	9,020		11,199		13,944
Selling, general and administrative	48,454		35,714		11,772
Total stock-based compensation expense	$	64,459	$	50,925	$	30,278

Summary of RSU Activity

Activity with respect to the Company’s restricted stock units during the year ended September 30, 2025 is as follows:


(In thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2024	1,964	$	32.13
Granted	1,266	$	45.75
Vested/Issued	(947)	39.12
Forfeited	(401)	34.74
Nonvested shares at September 30, 2025	1,882	$	37.21

Summary of PSU Activity

Activity under the PSUs during the year ended September 30, 2025 is summarized below:


(In thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2024	1,166	$	27.01
Granted	1,422	$	47.07
Vested/Issued	(311)	44.90
Forfeited	(343)	32.82
Nonvested shares at September 30, 2025	1,934	$	37.85

Summary of Share-based Payment Arrangement, Option, Activity

Options activity during the year ended September 30, 2025 is summarized below:


(In thousands, except per share and contractual term data)	Shares	Weighted average exercise price per share		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Outstanding at September 30, 2024	1,892	$	29.60	4.57	$	37,840
Forfeited	(132)	55.78		—	$	—
Exercised	(484)	19.31		—	10,571
Outstanding at September 30, 2025	1,276	$	30.80	3.59	$	6,616

Vested and exercisable at September 30, 2025	1,275	$	30.79	3.59	$	6,616

Summary of Shares Reserved For Issuance

The number of shares reserved for issuance as of September 30, 2025 is as follows:


(In thousands)						Shares available
As of September 30, 2024						611
Additional shares authorized						249
Shares issued during the period						(144)
As of September 30, 2025						716

Investment in Equity Securities - Assets and Liabilities Transferred (Details) - USD ($) $ in Thousands		12 Months Ended
	May 02, 2025	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Sale consideration:
Fair value of Series Seed-1 Preferred Stock		$ 53,890	$ 0	$ 0
Net assets sold:
Gain on sale of business		48,847	$ 0	$ 0
Disposal Group, Disposed of by Sale, Not Discontinued Operations \| DNA Digital Data Storage
Sale consideration:
Fair value of promissory note receivable		1,700
Atlas Data Storage, Inc \| Disposal Group, Disposed of by Sale, Not Discontinued Operations \| DNA Digital Data Storage
Sale consideration:
Fair value of Series Seed-1 Preferred Stock	$ 53,890
Fair value of promissory note receivable	1,696
Upfront cash consideration	2,500
Sale consideration:	58,086
Net assets sold:
Property and equipment	(5,623)
Goodwill	(3,616)
Net assets sold:	(9,239)
Gain on sale of business	$ 48,847	$ 48,800

Net Loss Per Share Attributable to Common Stockholders - Calculation of Diluted Net Loss Per Share (Details) - shares shares in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	5,192	5,090	5,078
Shares subject to options to purchase common stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	1,276	1,891	2,408
Unvested restricted stock units and performance stock units
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	3,816	3,130	2,552
Shares subject to employee stock purchase plan
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	100	69	118

Goodwill and Intangible Assets - Intangible Assets Balances (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Intangible Asset, Acquired, Finite-Lived [Line Items]
Gross carrying amount	$ 17,900	$ 66,130
Impairment	(4,475)	(35,864)	$ 0
Accumulated amortization		(15,788)
Intangible assets, net	$ 13,425	$ 14,478
Developed Technology
Intangible Asset, Acquired, Finite-Lived [Line Items]
Weighted average Amortization period in years	17 years	17 years
Gross carrying amount	$ 17,900	$ 50,020
Impairment	(4,475)	(25,198)
Accumulated amortization		(10,344)
Intangible assets, net	$ 13,425	14,478
Customer Relationships
Intangible Asset, Acquired, Finite-Lived [Line Items]
Gross carrying amount		15,210
Impairment		(10,541)
Accumulated amortization		(4,669)
Intangible assets, net		0
Tradenames & Trademarks
Intangible Asset, Acquired, Finite-Lived [Line Items]
Gross carrying amount		900
Impairment		(125)
Accumulated amortization		(775)
Intangible assets, net		$ 0

Income Taxes (Tables)

12 Months Ended

Sep. 30, 2025

Income Tax Disclosure [Abstract]

Summary of Domestic and Foreign Components of Pre-Tax Loss

The domestic and foreign components of pre-tax loss for the years ended September 30, 2025, 2024, and 2023 are as follows:


	Year ended September 30,
(in thousands)	2025		2024		2023
US	$	(78,490)	$	(209,545)	$	(205,389)
Foreign	1,539		1,379		1,923
Total	$	(76,951)	$	(208,166)	$	(203,466)

Summary of Components of the Provision for Income Taxes

The components of the income tax expense for the years ended September 30, 2025, 2024, and 2023 are as follows:


	Year ended September 30,
(in thousands)	2025		2024		2023
Current
Federal	$	—	$	—	$	—
State	27		20		9
Foreign	692		540		1,143
Total current	$	719	$	560	$	1,152

Deferred
Federal	$	—	$	—	$	—
State	—		—		—
Foreign	—		—		—
Total deferred	$	—	$	—	$	—

Total provision (benefit)	$	719	$	560	$	1,152

Summary of Effective Income Tax Rate Reconciliation

The following is a reconciliation of the statutory federal income tax rate to the Company’s effective tax rate for the years ended September 30, 2025, 2024, and 2023:


	Year ended September 30,
	2025		2024		2023
Tax expense computed at the federal statutory rate	21	%	21	%	21	%
Change in valuation allowance	(22)	%	(22)	%	(25)	%
Research and development credit benefit	7	%	3	%	5	%
Section 162(m) limitation on compensation	(9)	%	(1)	%	—	%
Stock-based compensation	1	%	(1)	%	(1)	%
Change in fair value of contingent consideration and holdbacks	—	%	—	%	1	%
Gain on sale of intangible assets	1	%	—	%	—	%
Others	—	%	—	%	(2)	%
Total income tax expense	(1)	%	—	%	(1)	%

Summary of Deferred Tax Assets and Liabilities

The significant components of the Company’s deferred tax assets and liabilities are as follows for the years ended September 30, 2025, and 2024:


	September 30,
(in thousands)	2025		2024
Net operating loss carryforwards	$	232,380	$	226,959
Research and development credit carryforwards	67,626		59,578
Capitalized research and development	54,438		43,232
Operating lease liability	18,657		21,377
Stock-based compensation	13,359		13,384
Other	12,333		14,310
Gross deferred tax assets	$	398,793	$	378,840
Less: Valuation allowance	(383,378)		(360,594)
Net deferred tax assets	$	15,415	$	18,246
Operating lease right-of-use asset	$	(12,174)	$	(14,786)
Intangible assets	(3,241)		(3,460)
Gross deferred tax liabilities	$	(15,415)	$	(18,246)
Total net deferred tax asset	$	—	$	—

Summary of Unrecognized Tax Benefits Roll Forward

The aggregate changes in the balance of gross unrecognized tax benefits are as follows:


	Federal and state
	September 30,
(in thousands)	2025		2024		2023
Unrecognized tax benefits at beginning of year	$	22,412	$	19,185	$	13,383
Increase related to tax positions taken during year	2,617		3,354		5,043
Increase/(decrease) related to tax positions taken in the prior year	259		(127)		759
Unrecognized tax benefits at end of year	$	25,288	$	22,412	$	19,185

Leases - Future Minimum Lease Payments and Sublease Income (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Operating leases
2026	$ 13,963
2027	8,450
2028	8,510
2029	6,609
2030	6,787
Thereafter	74,618
Total minimum lease payments	118,937
Less: imputed interest	(43,365)
Total operating lease liabilities	75,572
Less: current portion	(13,822)	$ (14,805)
Operating lease liabilities, net of current portion	61,750	$ 70,221
Sublease income
2026	1,918
2027	1,975
2028	2,035
2029	0
2030	0
Thereafter	0
Total minimum lease payments	$ 5,928

Cash, Cash Equivalent and Short-term Investments

12 Months Ended

Sep. 30, 2025

Cash and Cash Equivalents [Abstract]

Cash, Cash Equivalent and Short-term Investments

The following table sets forth the cash and cash equivalents, and investments as of September 30, 2025:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash	$	32,677	$	—	$	—	$	32,677
Cash equivalents - money market funds	150,372		—		—		150,372
Total cash and cash equivalents	$	183,049	$	—	$	—	$	183,049
Short-term investments:
U.S. government treasury bills	$	49,316	$	69	$	—	$	49,385
Total short-term investments	$	49,316	$	69	$	—	$	49,385
Total cash, cash equivalents and short-term investments	$	232,365	$	69	$	—	$	232,434

The following table sets forth the cash and cash equivalents, and investments as of September 30, 2024:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash	$	26,458	$	—	$	—	$	26,458
Cash equivalents - money market funds	199,858		—		—		199,858
Total cash and cash equivalents	$	226,316	$	—	$	—	$	226,316
Short-term investments:
U.S. government treasury bills	$	49,964	$	119	$	—	$	50,083
Total short-term investments	$	49,964	$	119	$	—	$	50,083
Total cash, cash equivalents and short-term investments	$	276,280	$	119	$	—	$	276,399

During the years ended September 30, 2025, 2024 and 2023, gross realized gains and losses related to our short-term investments were not material.

During the years ended September 30, 2025, 2024 and 2023, the Company did not recognize any credit losses.

Income Taxes - Provision for Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Current
Federal	$ 0	$ 0	$ 0
State	27	20	9
Foreign	692	540	1,143
Total current	719	560	1,152
Deferred
Federal	0	0	0
State	0	0	0
Foreign	0	0	0
Total deferred	0	0	0
Total provision (benefit)	$ 719	$ 560	$ 1,152

Balance Sheet Components

12 Months Ended

Sep. 30, 2025

Balance Sheet Related Disclosures [Abstract]

Balance Sheet Components

Allowance for Credit Losses

Allowance for credit losses related to accounts receivable were $0.6 million and $0.7 million as of September 30, 2025 and 2024, respectively.

Inventories

Inventories consist of the following:


	September 30,
(in thousands)	2025		2024
Raw Materials	$	20,191	$	17,316
Work-in-process	2,265		2,146
Finished Goods	5,853		4,616
	$	28,309	$	24,078

Property and Equipment, net

Property and equipment, net consists of the following:


	September 30,
(in thousands)	2025		2024
Laboratory equipment	$	101,583	$	99,528
Furniture, fixtures and other equipment	2,905		2,944
Vehicles	211		211
Computer equipment	3,176		3,249
Computer software	11,009		10,095
Leasehold improvements	58,277		57,448
Construction in progress	20,116		4,688
	$	197,277	$	178,163
Less: Accumulated depreciation and amortization	(94,994)		(75,643)
	$	102,283	$	102,520

Construction in progress mainly represents equipment costs, leasehold improvements, and internal use software development costs. For the year ended September 30, 2025 and 2024 the total depreciation and amortization expense was $23.8 million and $27.3 million, respectively. During the year ended September 30, 2024, the Company recognized impairment of property and equipment of $44.9 million, (see Note 18).

The net book value of capitalized computer software held for internal use included in property and equipment, net were $3.2 million and $5.2 million as of September 30, 2025 and 2024, respectively. For the year ended September 30, 2025 and 2024, the amortization expense of capitalized computer software held for internal use was $2.9 million and $2.6 million, respectively.

Property and equipment, net located in the United States were $102.3 million and $102.3 million as of September 30, 2025 and 2024, respectively. Property and equipment, net located outside of the United States were immaterial and $0.2 million as of September 30, 2025 and 2024, respectively.

Other Current Liabilities

Other current liabilities consist of the following:


	September 30,
(in thousands)	2025		2024
Income and other taxes payable	$	4,543	$	2,725
Contract liabilities	6,884		2,131
Other current liabilities	722		961
	$	12,149	$	5,817

Organization and Description of Business	12 Months Ended
Organization and Description of Business	Sep. 30, 2025
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization and Description of Business	Organization and Description of Business Twist Bioscience Corporation (the "Company") was incorporated in the state of Delaware on February 4, 2013. The Company is a leading, rapidly growing synthetic biology company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the Company's platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. The Company has combined our silicon-based DNA writing technology with proprietary software, scalable commercial infrastructure and an e-commerce platform to create an integrated technology platform that enables us to achieve high levels of quality, precision, automation, and manufacturing throughput at a significantly lower cost than our competitors. The Company has applied its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next generation sequencing ("NGS"), sample preparation, and antibody libraries for drug discovery and development, all designed to enable its customers to conduct research more efficiently and effectively. The Company has leveraged the same technology to expand its footprint beyond DNA synthesis to manufacture synthetic RNA as well as antibody proteins to disrupt and innovate within larger market opportunities, in addition to discovery partnerships for biologic drugs. On May 2, 2025, the Company executed the Contribution Agreement (the "Contribution Agreement") pursuant to which the Company sold its DNA Data Storage business to Atlas Data Storage, Inc. ("Atlas"), a newly formed company, that will focus solely on DNA data storage technology and commercialization (see note 6). The Company has recognized annual losses from operations since inception and has an accumulated deficit of $1,319.6 million as of September 30, 2025. The Company incurred net losses of $77.7 million, $208.7 million and $204.6 million for the years ended September 30, 2025, 2024, and 2023, respectively. As of September 30, 2025, the Company had cash and cash equivalents of $183.0 million and short-term investments of $49.4 million. The Company expects that its current cash, cash equivalents, and short-term investments will be sufficient to fund its operations for a period of at least one year from the date the Consolidated Financial Statements are issued.

Stock-based Compensation

12 Months Ended

Sep. 30, 2025

Share-Based Payment Arrangement [Abstract]

Stock-based Compensation

2018 Equity Incentive Plan

On September 26, 2018, the board of directors adopted the 2018 Equity Incentive Plan (the 2018 Plan) as a successor to the 2013 Stock Plan (the 2013 Plan). In February 2025, as approved at the Annual Shareholders meeting, the Company amended its 2018 Plan, to increase the authorized shares issuable under the 2018 Plan by 3.7 million shares and eliminate the “evergreen” provision which provides for an automatic annual increase in the number of shares reserved for issuance of future awards under the Plan. The maximum aggregate number of shares that may be issued under the 2018 Plan was 10,068,911 of the Company’s common stock.

On August 22, 2023, the board of directors adopted an inducement equity incentive plan (the "Inducement Plan"). In February 2025, as approved at the Annual Shareholders meeting, the Company amended its Inducement Plan to increase the authorized shares issuable under the Inducement Plan by 700,000 shares. The maximum aggregate number of shares that may be issued under the Inducement Plan is 1,400,000 of the Company's common stock. The Inducement Plan permits the grant of non-statutory stock options, restricted stock, restricted stock units, stock appreciation rights, performance units and performance shares.

As of September 30, 2025, a total of 5,260,083 shares of the Company’s common stock have been reserved for issuance in connection with grant of future awards under the 2018 Plan and the Inducement Plan.

Any shares subject to outstanding awards under the 2013 Plan that are canceled or repurchased subsequent to the 2018 Plan’s effective date are returned to the pool of shares reserved for issuance under the 2018 Plan. Awards granted under the 2018 Plan may be non-statutory stock options, stock appreciation rights, restricted stock, restricted stock units, performance shares, and performance units.

Stock-based Compensation

Total stock-based compensation expense recognized were as follows:


	Year ended September 30,
(in thousands)	2025		2024		2023
Cost of revenues	$	6,985	$	4,012	$	4,562
Research and development	9,020		11,199		13,944
Selling, general and administrative	48,454		35,714		11,772
Total stock-based compensation expense	$	64,459	$	50,925	$	30,278

An immaterial amount of stock-based compensation expense was capitalized to inventories attributable to employees who support the manufacturing of the Company's products for the years ended September 30, 2025, 2024, and 2023. The balance sheet as of September 30, 2025 and 2024 includes $1.3 million and $1.3 million, respectively, of stock-based compensation expense primarily related to internal use software development costs was capitalized in property and equipment.

The total amount of share-based liabilities settled was $5.9 million for the year ended September 30, 2023. The settlement of the liabilities related to the issuance of contingent consideration and indemnity holdbacks associated with Abveris and iGenomX acquisition.

Restricted Stock Units

Restricted stock consists of restricted stock unit awards (RSUs) which have been granted to employees and non-employee directors. The value of an RSU award is based on the Company’s stock price on the date of grant. Employee grants generally vest over four years and non-employee director grants generally vest over one year. Forfeitures of RSUs are recognized as they occur. The shares underlying the RSU awards are not issued until the RSUs vest. Upon vesting, each RSU converts into one share of the Company’s common stock.

Activity with respect to the Company’s restricted stock units during the year ended September 30, 2025 is as follows:


(In thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2024	1,964	$	32.13
Granted	1,266	$	45.75
Vested/Issued	(947)	39.12
Forfeited	(401)	34.74
Nonvested shares at September 30, 2025	1,882	$	37.21

As of September 30, 2025, there was $64.8 million of total unrecognized compensation cost related to these issuances that is expected to be recognized over a weighted average period of 2.7 years. The total grant date fair value of RSUs awarded during the year ended September 30, 2025, 2024 and 2023 were $57.9 million, $42.7 million and $32.2 million, respectively. The total grant date fair value of RSUs vested during the year ended September 30, 2025, 2024 and 2023 were $37.0 million, $31.0 million and $33.7 million, respectively.

Performance-based Restricted Stock Units

During the year ended September 30, 2025, the Company granted additional performance-based restricted stock units to executives and employees that will vest upon achievement of multiple year revenue, gross margin, and profitability metrics as determined by the board of directors. Stock compensation expense for these awards is recorded over the vesting period based on the grant date fair value of the awards and probability of the achievement of specified performance targets. The grant date fair value is equal to the closing share price of the Company’s common stock on the date of grant. These awards will vest from a minimum of 10 months to a maximum of 34 months service period following the grant date, provided that the recipient is a Company employee at the time of vesting and the performance targets applicable to each award are achieved. The actual number of awards that ultimately vest will depend on the achievement of specified performance targets at the end of the performance period and can range from 0% to 140% of the number of units granted.

Activity under the PSUs during the year ended September 30, 2025 is summarized below:


(In thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2024	1,166	$	27.01
Granted	1,422	$	47.07
Vested/Issued	(311)	44.90
Forfeited	(343)	32.82
Nonvested shares at September 30, 2025	1,934	$	37.85

As of September 30, 2025, the unrecognized compensation costs related to these awards was $37.8 million, based on the maximum achievement of the performance targets. The Company expects to recognize those costs over a weighted average period of 1.6 years. The total grant date fair value of PSUs awarded during the year ended September 30, 2025, 2024 and 2023 were $66.9 million, $11.5 million and $21.2 million, respectively. The total grant date fair value of PSUs vested during the year ended September 30, 2025, 2024 and 2023 were $14.0 million, $6.9 million and $1.8 million, respectively.

Options

Options are generally granted to employees and were granted to non-employee directors until fiscal year 2022. Stock options entitle the holder to purchase, at the end of the vesting term, a specified number of shares of Company common stock at an exercise price per share equal to the closing market price of the common stock on the date of grant. Stock options have a contractual life from the date of the grant and a vesting schedule as established by the board of directors. The maximum term of stock options granted under the 2018 Plan is 10 years and the awards generally vest over a four-year period. Forfeitures of options are recognized as they occur. The fair value of each services based stock option grant is estimated on the date of grant using the Black-Scholes option-pricing model. The Company historically had been a private company and lacked company-specific historical and implied volatility information for its stock. Therefore, it estimated its expected stock price volatility based on the historical volatility of publicly traded peer companies and utilized the “simplified” method for awards that qualify as “plain-vanilla” options. As determined under the simplified method, the expected term of stock options granted is calculated based on contractual and vesting terms of the option award, the risk-free interest rate is determined by reference to the U.S. Treasury yield curve in effect at the time of grant of the award for time periods approximately equal to the expected term of the award and the expected dividend yield is zero based on the fact that the Company has never paid cash dividends on common stock and does not expect to pay any cash dividends in the foreseeable future.

Options activity during the year ended September 30, 2025 is summarized below:


(In thousands, except per share and contractual term data)	Shares	Weighted average exercise price per share		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Outstanding at September 30, 2024	1,892	$	29.60	4.57	$	37,840
Forfeited	(132)	55.78		—	$	—
Exercised	(484)	19.31		—	10,571
Outstanding at September 30, 2025	1,276	$	30.80	3.59	$	6,616

Vested and exercisable at September 30, 2025	1,275	$	30.79	3.59	$	6,616

As of September 30, 2025, the unrecognized compensation costs related to these awards was immaterial. The Company expects to recognize those costs over a weighted average period of 0.2 years. The Company did not grant any options during the year ended September 30, 2025, 2024 and 2023. The aggregate intrinsic value of stock options exercised during the year ended September 30, 2024 and 2023 were $9.2 million and $1.1 million, respectively.

2018 Employee Stock Purchase Plan

On September 26, 2018, the board of directors adopted the 2018 Employee Stock Purchase Plan (the 2018 ESPP). A total of 275,225 shares of the Company’s common stock were originally reserved for issuance under the 2018 ESPP. The number of shares reserved for issuance under the 2018 ESPP will be increased automatically on the first day of each fiscal year, following the fiscal year in which the 2018 ESPP becomes effective, by a number equal to the least of 249,470 shares, 1% of the shares of common stock outstanding at that time, or such number of shares determined by the Company’s board of directors. The number of shares reserved for issuance as of September 30, 2025 is as follows:


(In thousands)						Shares available
As of September 30, 2024						611
Additional shares authorized						249
Shares issued during the period						(144)
As of September 30, 2025						716

Subject to any plan limitations, the 2018 ESPP allows eligible service providers (through qualified and non-qualified offerings) to contribute, normally through payroll deductions, up to 15% of their earnings for the purchase of the Company’s common stock at a discounted price per share. The offering periods are beginning in February and August of each year, except the initial offering period which commenced with the initial public offering in October 2018 and ended on August 20, 2019.

Unless otherwise determined by the board of directors, the Company’s common stock will be purchased for the accounts of employees participating in the 2018 ESPP at a price per share that is the lesser of 85% of the fair market value of the Company’s common stock on the first trading day of the offering period, which for the initial offering period is the price at which shares of the Company’s common stock were first sold to the public, or 85% of the fair market value of the Company’s common stock on the last trading day of the offering period. During the years ended September 30, 2025 and 2024, the Company recorded $2.4 million and $1.6 million expense related to the 2018 ESPP. During the year ended September 30, 2023 activity under the 2018 ESPP was immaterial.

401(k) Savings Plan

During 2018, the Company adopted a 401(k) savings plan for the benefit of its employees. In January 2022, the Company modified its plan to include an employer matching contribution. The Company is required to make matching contributions to the 401(k) plan equal to 50% of the first 6% of wages deferred by each participating employee. For the year ended September 30, 2025 and 2024, the Company incurred expenses for employer matching contributions of $3.0 million and $2.6 million, respectively.

Liability Related to the Sales of Future Revenue (Details) - USD ($) $ in Millions	Sep. 30, 2025	Oct. 21, 2024
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Liability related to the sale of future revenue	$ 15.0	$ 15.0

Cash, Cash Equivalent and Short-term Investments (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Cash and Cash Equivalents [Line Items]
Cash and cash equivalents	$ 183,049	$ 226,316
Short term investments, Amortized cost	49,316	49,964
Gross unrealized gains	69	119
Gross unrealized losses	0	0
Short term investments, fair value	49,385	50,083
Total cash, cash equivalents and short-term investments, amortized cost	232,365	276,280
Total cash, cash equivalents and short-term investments	232,434	276,399
U.S. government treasury bills
Cash and Cash Equivalents [Line Items]
Short term investments, Amortized cost	49,316	49,964
Gross unrealized gains	69	119
Gross unrealized losses	0	0
Short term investments, fair value	49,385	50,083
Cash
Cash and Cash Equivalents [Line Items]
Cash and cash equivalents	32,677	26,458
Money market funds
Cash and Cash Equivalents [Line Items]
Cash and cash equivalents	$ 150,372	$ 199,858

Goodwill and Intangible Assets (Tables)

12 Months Ended

Sep. 30, 2025

Goodwill and Intangible Assets Disclosure [Abstract]

Summary of Goodwill

The goodwill balance is presented below:


	September 30,
(in thousands)	2025		2024
Balance at beginning of year	$	85,811	$	85,811
Sale of business (see note 6)	(3,616)		—
Balance at end of year	$	82,195	$	85,811

Summary of Intangible Assets Balances

The finite-lived intangible assets balances are presented below:


	September 30, 2025
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Accumulated amortization		Net book value
Developed Technology	17	$	17,900	$	(4,475)	$	13,425
Total finite-lived intangible assets		$	17,900	$	(4,475)	$	13,425


	September 30, 2024
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Impairment		Accumulated amortization		Net book value
Developed Technology	17	$	50,020	$	(25,198)	$	(10,344)	$	14,478
Customer Relationships	—	15,210		(10,541)		(4,669)		—
Tradenames & Trademarks	—	900		(125)		(775)		—
Total finite-lived intangible assets		$	66,130	$	(35,864)	$	(15,788)	$	14,478

Summary of Finite-Lived Intangible Assets, Future Amortization Expense

Future annual amortization expense is as follows (in thousands):


Years ending September 30,
2026	$	1,053
2027	1,053
2028	1,053
2029	1,053
2030	1,053
Thereafter	8,160
	$	13,425

- Definition

Tabular disclosure of goodwill by reportable segment and in total which includes a rollforward schedule.

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+ Details

Goodwill and Intangible Assets - Narrative (Details) - USD ($) $ in Millions	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Goodwill and Intangible Assets Disclosure [Abstract]
Amortization expense related to intangible assets	$ 1.1	$ 4.1	$ 5.3

- Definition

The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets.

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+ Details

Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Statement of Comprehensive Income [Abstract]

Revenues

^[1]

$ 376,572

$ 312,974

$ 245,109

Costs and expenses:

Cost of revenues

185,570

179,625

155,380

Research and development expenses

80,285

90,852

106,894

Selling, general and administrative expenses

246,976

218,398

189,738

Restructuring and other costs

9,384

Change in fair value of contingent considerations and holdbacks

(5,913)

Impairment of long-lived assets

44,930

6,785

Total costs and expenses

512,831

533,805

462,268

Loss from operations

(136,259)

(220,831)

(217,159)

Gain on sale of business

48,847

Interest income

11,364

15,344

14,365

Other income (expense), net

^[2]

(903)

(2,679)

(672)

Loss before income taxes

(76,951)

(208,166)

(203,466)

Income tax expense

(719)

(560)

(1,152)

Net loss attributable to common stockholders

(77,670)

(208,726)

(204,618)

Other comprehensive income (loss):

Change in unrealized gain (loss) on investments

(50)

203

1,510

Foreign currency translation adjustment

(55)

(423)

Comprehensive loss

$ (77,775)

$ (208,492)

$ (203,531)

Net loss per share attributable to common stockholders—basic (in dollars per share)

$ (1.30)

$ (3.60)

Net loss per share attributable to common stockholders—diluted (in dollars per share)

$ (1.30)

$ (3.60)

Weighted average shares used in computing net loss per share attributable to common stockholders—basic (in shares)

59,808,000

58,016,000

56,885,000

Weighted average shares used in computing net loss per share attributable to common stockholders—diluted (in shares)

59,808,000

58,016,000

56,885,000

[1]	Including revenues from related parties of $12.2 million, $12.1 million and $5.9 million during the year end September 30, 2025, 2024 and 2023, respectively.
[2]	Including sublease income from a related party of $1.1 million, $— million and $— million during the year end September 30, 2025, 2024 and 2023, respectively.

Summary of Significant Accounting Policies (Policies)	12 Months Ended
Summary of Significant Accounting Policies (Policies)	Sep. 30, 2025
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The consolidated financial statements, which include the Company’s accounts and the accounts of its wholly-owned subsidiaries, are prepared in accordance with U.S. generally accepted accounting principles (or “GAAP”). All intercompany balances and accounts are eliminated in consolidation.
Use of Estimates	Use of Estimates The presentation of consolidated financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the consolidated financial statements and the reported amounts of revenue and expenses during the reporting period. Such estimates include the valuation of deferred tax assets, stock-based compensation expense, transaction price and progress toward completion of performance obligation under the contracts with customers, determination of the net realizable value of inventory, useful life of developed technology, valuation assumptions used in the calculation of the impairment of long-lived assets, restructuring costs and incremental borrowing rate for operating leases. Actual results could differ from those estimates.
Concentration of Credit Risk	Concentration of Credit Risk Financial instruments that potentially subject the Company to a concentration of credit risk consist of cash and cash equivalents, short-term investments and accounts receivable. Substantially all of the Company’s cash and cash equivalents, short-term investments are held with two financial institutions that management believe are of high credit quality. Such deposits may, at times, exceed federally insured limits. The Company’s investment policy addresses the level of credit exposure by establishing a minimum allowable credit rating and by limiting the concentration in any one investment. The Company’s accounts receivable is derived from customers located principally in the United States, Europe and Asia-Pacific region ("APAC"). The Company performs ongoing credit evaluations of its customers and maintains allowances for potential credit losses on customers’ accounts when deemed necessary. The Company does not typically require collateral from its customers. Credit losses historically have not been material. See Note 3, Revenues, for more information for customer concentration.
Cash and Cash Equivalents and Restricted Cash	Cash and Cash Equivalents and Restricted Cash Cash equivalents that are readily convertible to cash are stated at cost, which approximates fair value. The Company considers all highly liquid investments with an original or remaining maturity of three months or less at the time of purchase to be cash equivalents. Cash equivalents consist of investments in money market funds as of September 30, 2025 and 2024. Restricted cash represents cash held at financial institutions that are pledged as collateral for stand-by letters of credit for lease commitments. The lease related letters of credit will lapse at the end of the respective lease terms through 2044.
Short-term Investments	Short-term Investments The Company invests in various types of securities, including United States government, commercial paper, and corporate debt securities. The Company classifies its investments as available-for-sale and records them at fair value based upon market prices at period end. The Company regularly reviews its short-term investments to identify and evaluate investments that have indications of possible impairment from credit losses or other factors. For available-for-sale debt securities in an unrealized loss position, the Company evaluates whether a current expected credit loss exists based on available information relevant to the credit rating of the security, current economic conditions and supportable forecasts. The allowance for credit loss is recorded in other income (expense), net, on the consolidated statements of operations and comprehensive loss, not to exceed the amount of the unrealized loss. Any excess unrealized loss other than the credit loss is recognized in accumulated other comprehensive income or loss in the stockholders' equity section of the consolidated balance sheets. The Company made an accounting policy election to not measure an allowance for credit losses for accrued interest receivable. The accrued interest balance as of September 30, 2025 and 2024 was $1.2 million and $1.1 million. There was no allowance for credit losses relating to the short-term investments recognized as of September 30, 2025. The cost of securities sold is based on the specific identification method and realized gains and losses are included in other income (expense), net. Dividend and interest income are recognized when earned. The Company may sell these securities at any time for use in current operations.
Accounts Receivable and Allowance for Credit Losses	Accounts Receivable and Allowance for Credit Losses Accounts receivables include amounts billed and currently due from customers, recorded at the net invoice value and are not interest bearing. The Company has a short order-to-invoice lifecycle, as most products can be manufactured within one month. Upon delivery of the products to the customer, the Company invoices the customer. The typical timing of payment is net 30 days. If the right to payment for services performed was conditional on something other than the passage of time, the unbilled amount would be recorded as a separate contract asset. The Company is exposed to credit losses primarily through accounts receivable from sales of its products and services. The Company maintains an allowance for credit losses for expected uncollectible accounts receivable and contract assets, which is recorded as an offset to accounts receivable or contract assets and provisions for credit losses are recorded in selling, general and administrative expense in the consolidated statements of operations and comprehensive loss. The allowance for current expected credit losses is based on a review of customer accounts and considers historical credit loss information that is adjusted for current economic and business conditions and anticipated future economic events that may impact collectability. In developing its expected credit loss estimate, the Company evaluated the appropriate grouping of accounts receivable and contract assets based upon its evaluation of risk characteristics, including consideration of region and industries of the customers. Specific allowance amounts are established to record the appropriate provision for customers that have a higher probability of default. The allowance for credit losses is reviewed on a regular basis to assess the adequacy of the allowance and once a receivable is deemed to be uncollectible, such balance is charged against the allowance.
Fair Value of Financial Instruments	Fair Value of Financial Instruments The Company applies fair value accounting for all financial and non-financial assets and liabilities that are recognized or disclosed at fair value in the financial statements on a recurring basis. The Company defines fair value as the price that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. When determining the fair value measurements for assets and liabilities which are required to be recorded at fair value, we consider the principal or most advantageous market in which we would transact and the market-based risk measurements or assumptions that market participants would use in pricing the asset or liability, such as risks inherent in valuation techniques, transfer restrictions and credit risks. See Note 5, Fair value measurements, for more information. The carrying amounts of the Company’s financial instruments including cash equivalents, short term investments, and accounts receivable approximate fair value due to their relatively short maturities.
Inventories	Inventories Inventories are stated at the lower of cost or net realizable value. Cost is computed using standard cost which approximates actual cost on a first-in, first-out basis. The Company periodically reviews its inventories to identify obsolete, slow-moving, excess or otherwise unsaleable items. If obsolete, slow-moving, excess or unsaleable items are observed and there are no alternate uses for the inventory, the Company records a write-down to net realizable value through a charge to cost of revenues on our consolidated statements of operations and comprehensive loss. The determination of net realizable value requires judgment, including consideration of many factors, such as estimates of future product demand, past experience, product net selling prices, current and future market conditions, the age and nature of inventories, and potential product obsolescence, among others.
Property and Equipment	Property and Equipment Property and equipment are stated at cost less accumulated depreciation and amortization. Depreciation and amortization are computed using the straight-line method over the estimated useful lives of the assets or the lesser of the useful life and the remaining lease term of the respective leasehold improvements assets, if any. Upon retirement or sale, the cost of assets disposed of and the related accumulated depreciation are eliminated from the accounts and any resulting gain or loss is credited or charged to operations in the period recognized. Repairs and maintenance costs are expensed as incurred.
Capitalized Software Held for Internal Use	Capitalized Software Held for Internal Use Costs associated with internal-use software systems during the application development stage are capitalized. Capitalization of costs begins when the preliminary project stage is completed, management has committed to funding the project, and it is probable that the project will be completed and the software will be used to perform the function intended. Costs include external direct costs of services and applicable personnel costs of employees devoted to specific software application development. Personnel costs consist of salaries, employee benefit costs, bonuses and stock-based compensation expense. The capitalized amounts are included in property and equipment, net on the consolidated balance sheets. Capitalization ceases at the point when the project is substantially complete and is ready for its intended purpose. Capitalized costs are amortized from the project completion date, using the straight-line method over an estimated useful life of the assets.
Finite-lived Intangible Assets	Finite-lived Intangible Assets Finite-lived intangible assets are recorded at cost, net of accumulated amortization, and, if applicable, impairment charges. Amortization of finite-lived intangible assets is recorded over the assets’ estimated useful lives on a straight-line basis or based on the pattern in which economic benefits are consumed, if reliably determinable. The Company reviews the finite-lived intangible assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable.
Impairment of Long-lived Assets	Impairment of Long-lived Assets The Company's long-lived assets consists of property and equipment, right of use assets and finite-lived intangible assets. The Company evaluates long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. If indicators of impairment are present, the Company tests for recoverability by comparing the estimated undiscounted future cash flows expected to result from the use of the asset over its remaining useful life to the carrying amount of the asset or asset group. If the asset or asset group is determined to be impaired, any excess of the carrying value of the asset or asset group over its estimated fair value is recognized as an impairment loss. Impairment assessments inherently involve judgment as to assumptions about expected future cash flows and the impact of market conditions on those assumptions.
Leases	Leases The Company determines if an arrangement is or contains a lease at inception and classifies each lease as operating or financing. Operating lease right-of-use assets represent the Company’s right to use an underlying asset for the lease term and lease liabilities represent the Company’s obligation to make lease payments made during the lease term, net of any tenant improvement allowance. Operating lease right-of-use assets and liabilities are recognized at the lease commencement date based on the present value of lease payments over the lease term. In determining the present value of committed lease payments, the Company uses its incremental borrowing rate based on the information available at the lease commencement date which includes significant assumptions made including the Company’s estimated credit rating, annual percentage yields from corporate debt financings of companies of similar size and credit rating over a loan term approximating the remaining term of each lease, and government bond yields for terms approximating the remaining term of each lease in countries where the leased assets are located. Certain leases include payments of operating expenses that are dependent on the landlord’s estimate, and these variable payments are therefore excluded from the lease payments used to determine the operating lease right-of-use asset and lease liability. Lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise any such options. Operating lease right-of-use assets are adjusted for prepaid lease payments, lease incentives and initial direct costs incurred. Lease expense is recognized on a straight-line basis over the expected lease term. The Company elected to not apply the recognition requirements of Topic 842 to short-term leases with terms of 12 months or less which do not include an option to purchase the underlying asset that the Company is reasonably certain to exercise. For short-term leases, lease payments are recognized as operating expenses on a straight-line basis over the lease term. The Company elected to account for lease and non-lease components as a single lease component.
Goodwill	Goodwill The company assesses goodwill for impairment at the reporting unit level annually and whenever events occur or circumstances change that would more likely than not reduce the fair value of a reporting unit below its carrying amount. Such events or circumstances generally include the occurrence of operating losses or a significant decline in earnings associated with one or more of the company’s reporting units. The company is permitted to first assess qualitative factors to determine whether the quantitative goodwill impairment test is necessary. If the qualitative assessment results in a determination that the fair value of a reporting unit is more likely than not less than its carrying amount, the company performs a quantitative goodwill impairment test. The company may bypass the qualitative assessment for the reporting unit in any period and proceed directly to the quantitative goodwill impairment test. The company estimates the fair value of its reporting unit by using forecasts of discounted future cash flows and peer market multiples. The company would record an impairment charge based on the excess of a reporting unit’s carrying amount over its fair value (limited to the amount of goodwill). For 2025 and 2024, the Company elected to proceed directly to the step-one assessment which indicated that the fair value of its single reporting unit substantially exceeded the carrying value.
Segment Information	Segment Information The Company is a synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology and manufactures synthetic genes, tools for next-generation sequencing preparation, and antibody libraries for drug discovery and development and operates as one reportable and operating segment. The Company’s chief operating decision-maker, its Chief Executive Officer (CEO), reviews the Company’s operating results on an aggregate basis for purposes of allocating resources and evaluating financial performance.
Foreign Currency Transactions and Translation	Foreign Currency Transactions and Translation The Company's consolidated financial statements are presented in U.S. dollars. The functional currency for certain foreign subsidiaries is their local currency. Revenues, expenses, gains and losses for non-U.S. dollar functional currency entities are translated into U.S. dollars using average currency exchange rates for the period. Assets and liabilities for such entities are translated using exchange rates that approximate the rate at the balance sheet date. Foreign currency translation adjustments are recorded as a component of accumulated other comprehensive loss on the Company's consolidated balance sheets. Foreign currency transaction gains and losses on transactions not denominated in functional currency are recorded in Other income (expense), net, on the consolidated statements of operations.
Revenue Recognition	Revenue Recognition The Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the Company expects to receive in exchange for those goods or services. To determine revenue recognition for contracts with customers, the Company performs the following five steps: i.identification of the promised goods or services in the contract; ii.determination of whether the promised goods or services are performance obligations including whether they are distinct in the context of the contract; iii.measurement of the transaction price, including the constraint on variable consideration; iv.allocation of the transaction price to the performance obligations based on estimated selling prices; and v.recognition of revenue when (or as) the Company satisfies each performance obligation. A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account. See Note 3, Revenue recognition, for detailed discussions of revenue recognition, and how the five steps described above are applied. Cost of Revenue Cost of revenues primarily consists of cost incurred in the production and delivery of the Company's products and consists of production materials, personnel costs, cost of expensed equipment and consumables, laboratory supplies, consulting costs, depreciation, production overhead costs, information technology, maintenance and facility costs. Personnel costs consist of salaries, employee benefit costs, bonuses, and stock-based compensation expense. In addition, cost of revenue includes royalty costs for licensed technologies included in the Company’s products, and provisions for slow-moving and obsolete inventory.
Research and Development	Research and Development Research and development expenses consist of compensation costs, employee benefits, subcontractors, research supplies, allocated facility related expenses and allocated depreciation and amortization. All research and development costs are expensed as incurred.
Advertising Costs	Advertising Costs Costs related to advertising and promotions are expensed to sales and marketing as incurred.
Stock-based Compensation	Stock-based Compensation The Company maintains performance incentive plans under which incentive and nonqualified stock options, performance-based stock options, restricted stock units, performance-based stock units and through employer purchase plan are granted primarily to employees and may be granted to members of the board of directors and certain non-employee consultants, and employees may participate in an employee stock purchase plan. The Company recognizes stock compensation in accordance with the Accounting Standard Codification ("ASC") 718, Compensation—Stock Compensation. ASC 718 requires the recognition of compensation expense, using a fair value-based method, for costs related to all stock-based payments including stock options, restricted stock units and employee stock purchase plan. The Company recognizes fair value of stock options granted to employees and non-employees as a stock-based compensation expense over the period in which the related services are received. The Company recognizes forfeitures as they occur. The Company believes that the estimated fair value of stock options is more readily measurable than the fair value of the services rendered. For performance-based awards, expense is recognized over the period from the grant date to the estimated attainment date, which is the derived service period of the award, if management determines that it is probable that the performance-based vesting conditions will be achieved.
Net Loss Per Share Attributable to Common Stockholders	Net Loss Per Share Attributable to Common Stockholders The Company calculates its basic and diluted net loss per share attributable to common stockholders in conformity with the two-class method required for companies with participating securities. In computing diluted net loss attributable to common stockholders, undistributed earnings are re-allocated to reflect the potential impact of dilutive securities. For purposes of the calculation of diluted net loss per share attributable to common stockholders, unvested shares of common stock issued upon the early exercise of stock options, shares issuable for employee stock purchase plan contributions received, warrants to purchase common stock, unvested restricted common stock, unvested restricted stock units and stock options to purchase common stock are considered potentially dilutive securities but have been excluded from the calculation of diluted net loss per share attributable to common stockholders as their effect is antidilutive. Basic and diluted net loss per share of common stock attributable to common stockholders is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, less shares subject to repurchase, and excludes any dilutive effects of employee stock-based awards and warrants. Because the Company has reported a net loss for the years ended September 30, 2025, 2024 and 2023, diluted net loss per common share is the same as the basic net loss per share for those years.
Income Taxes	Income Taxes The Company uses the asset and liability method of accounting for income taxes, in which deferred tax assets and liabilities are recognized for the future tax consequences attributable to the differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assets and liabilities are measured using the enacted tax rates expected to apply in the years in which those tax assets and liabilities are expected to be realized. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in the period that includes the enactment date. A valuation allowance is established if it is more likely than not that all or a portion of the deferred tax asset will not be realized. The Company’s tax positions are subject to income tax audits. The Company recognizes the tax benefit of an uncertain tax position only if it is more likely than not that the position is sustainable upon examination by the taxing authority, based on the technical merits. The tax benefit recognized is measured as the largest amount of benefit which is more likely than not (greater than 50% likely) to be realized upon settlement with the taxing authority. The Company recognizes interest accrued and penalties related to unrecognized tax benefits in its tax provision. The Company calculates the current and deferred income tax provision based on estimates and assumptions that could differ from the actual results reflected in income tax returns filed in subsequent years. Adjustments based on filed income tax returns are recorded when identified. The amount of income tax paid is subject to examination by U.S. and foreign tax authorities. The estimate of the potential outcome of any uncertain tax issue is subject to management’s assessment of the relevant risks, facts and circumstances existing at that time. To the extent the assessment of such tax position changes, the change in estimate is recorded in the period in which the determination is made.
Liability Related to the Sale of Future Revenue	Liability Related to the Sale of Future Revenue The Company accounts for the proceeds received from the monetization of future milestone and royalty payments from its contracts with certain customers as a debt instrument, which is amortized using the effective interest rate method over the estimated term of the arrangement. The Company recognizes interest expense thereon using the effective rate, which is based on its current estimates of future milestone and royalty payments under its customer contracts to be paid to the counterparty over the term of the arrangement. The Company periodically assesses these future estimated payments to impute interest on the carrying value of the liability. To the extent its estimates of future payments to the counterparty are greater or less than previous estimates or the estimated timing of such payments is materially different than previous estimates, the Company will account for any such changes by adjusting the effective interest rate on a prospective basis, with a corresponding impact to the liability. The assumptions used in determining the expected repayment term of the liability also requires that the Company makes estimates that could impact the classification of the liability, interest recorded on such liability, as well as the period over which such interest will be incurred.
Investment in equity securities	Investment in equity securities The Company determines at the inception of each arrangement whether an investment or other interest is considered a variable interest entity (“VIE”). If the investment or other interest is determined to be a VIE, the Company evaluates whether it is considered the primary beneficiary. The primary beneficiary of a VIE is the party that meets both of the following criteria: (i) has the power to direct the activities that most significantly impact the VIE’s economic performance; and (ii) has the obligation to absorb losses or the right to receive benefits from the VIE. For investments in VIEs in which the Company is considered the primary beneficiary, the assets, liabilities and results of operations of the VIE are included in the Company’s consolidated financial statements. For investments in common stock or in-substance common stock where the Company has significant influence over the financial and operating policies of the investee are accounted for as equity-method investments. If the Company's equity investment does not meet the requirements of equity method of accounting, the Company accounts for the investment at fair value and has elected to account for its equity investments without a readily determinable fair value using a measurement alternative. Equity investments without readily determinable fair values are recorded using the measurement alternative of cost less impairment, if any, adjusted for observable price changes in orderly transactions for identical or similar investments of the same issuer. Any impairments or adjustments are recorded in Other (income) expense, net on our consolidated statements of operations and comprehensive income (loss).
Contingent Consideration	Contingent Consideration The Company elected to account for the contingent consideration receivable under the Contribution Agreement with Atlas as a gain contingency in accordance with ASC 450, Contingencies (Subtopic 450-30). Under this approach, the Company recognizes the contingent consideration receivable in earnings after the contingency is resolved. Accordingly, to determine the initial gain on the sale of business, the Company did not include any amount related to the contingent consideration arrangement as part of the consideration received.
Business Combinations	Business Combinations The Company accounts for business combinations using the acquisition method. Under the acquisition method, the purchase price of the acquisition is allocated to the acquired tangible and identifiable intangible assets and assumed liabilities based on their estimated fair values at the time of the acquisition. This allocation involves a number of assumptions, estimates, and judgments that could materially affect the timing or amounts recognized in the Company’s financial statements. As a result, the Company may record adjustments to the fair values of assets acquired and liabilities assumed within the measurement period (up to one year from the acquisition date) with the corresponding offset to goodwill. The most subjective areas of the acquisition accounting method include determining the fair value of the following: •identifiable intangible assets, including the valuation methodology, estimates of projected revenues, technology obsolescence, and discount rates, as well as the estimated useful life of the intangible assets; •contingent consideration; and •goodwill, as measured as the excess of consideration transferred over the acquisition date fair value of the assets acquired, including the amount assigned to identifiable intangible assets, and the liabilities assumed. The assumptions and estimates are based upon comparable market data and information obtained from the management of the acquired business. Goodwill is assigned to reporting units that are expected to benefit from the synergies of the business combination as of the acquisition date. Identifiable intangible assets with finite lives are amortized over their estimated useful lives in a pattern in which the asset is consumed. Acquisition-related costs, including advisory, legal, accounting, valuation, and other similar costs, are expensed in the periods in which those costs are incurred. The results of operations of acquired businesses are included in the Company’s consolidated financial statements from the acquisition date.
Restructuring and Other Costs	Restructuring and Other Costs Restructuring and other costs are comprised of employee separation costs and other associated costs primarily related to implementing a plan. Employee separation costs principally consist of one-time termination benefits and contractual termination benefits for severance, other termination benefit costs, and stock-based compensation expense for the acceleration of stock awards. The Company records restructuring charges based on whether the termination benefits are provided under an on-going benefit arrangement or under a one-time benefit arrangement. The Company accounts for on-going benefit arrangements, such as those documented by employment agreements, in accordance with ASC 712, Nonretirement Postemployment Benefits. Under ASC 712, liabilities for post employment benefits are recorded at the time the obligations are probable of being incurred and can be reasonably estimated. The Company accounts for one-time employment benefit arrangements in accordance with ASC 420 Exit or Disposal Cost Obligations. One-time termination benefits are expensed at the date the entity notifies the employee, unless the employee must provide future service, in which case the benefits are expensed ratably over the future service period. Other associated costs are recognized in the period in which the liability is incurred.
Recent Accounting Pronouncements	Recent Accounting Pronouncements New Accounting Guidance Adopted In November 2023, the FASB issued ASU No. 2023-07 "Segment Reporting (Topic 280)". The amendments in this ASU improve reportable segment disclosure requirements, primarily through enhanced disclosures about significant segment expenses. The amendments in this update are effective for fiscal years beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. The Company adopted this ASU for our fiscal year ended September 30, 2025 and provided required disclosure in Note 16. Segment Information. New Accounting Guidance Issued but Not Yet Effective In December 2023, the FASB issued ASU No. 2023-09 "Income Taxes (Topic 740)". The amendments in this ASU require that public business entities on an annual basis (1) disclose specific categories in the rate reconciliation and (2) provide additional information for reconciling items that meet a quantitative threshold. The amendments in this update are effective for annual periods beginning after December 15, 2024. The standard is not expected to have a material impact to the Company's consolidated financial statements. In November 2024, the FASB issued ASU 2024-03, Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures, which will require additional expense disclosures for all public entities. The amendments require that at each interim and annual reporting period, an entity will disclose certain disaggregated expenses included in each relevant expense caption, as well as the total amount of selling expenses and, in annual periods, an entity’s definition of selling expenses. ASU 2024-03 is effective for fiscal years beginning after December 15, 2026, and interim periods within fiscal years beginning after December 15, 2027, with early adoption permitted. The Company is currently evaluating the incremental disclosures that will be required in its consolidated financial statements. In September 2025, the FASB issued ASU 2025-06, Intangibles - Goodwill and Other - Internal-Use Software (Subtopic 350-40): Targeted Improvements to the Accounting for Internal-Use Software ("ASU 2025-06"), which became effective and simplifies the capitalization guidance by removing all references to software development project stages so that the guidance is neutral to different software development methods. The standard is effective for all entities for annual periods beginning after December 15, 2027, with early adoption permitted. The Company is currently evaluating the impact of this standard to its consolidated financial statements. The Company has evaluated other recently issued accounting pronouncements and has concluded that the impact of recently issued standards that are not yet effective will not have a material impact on the Company’s financial position or results of operations upon adoption.

Leases (Tables)

12 Months Ended

Sep. 30, 2025

Leases [Abstract]

Summary of Future Minimum Lease Payments and Sublease Income

Future minimum lease payments and sublease income under all non-cancelable operating leases as of September 30, 2025 are as follows:


(in thousands)	Operating leases		Sublease income
Years ending September 30:
2026	$	13,963	$	1,918
2027	8,450		1,975
2028	8,510		2,035
2029	6,609		—
2030	6,787		—
Thereafter	74,618		—
Total minimum lease payments	$	118,937	$	5,928
Less: imputed interest	(43,365)
Total operating lease liabilities	$	75,572
Less: current portion	(13,822)
Operating lease liabilities, net of current portion	$	61,750

Summary of Lease Expense and Supplemental Information

The components of lease expense and supplemental information were as follows:


	September 30,
(in thousands except years and percentage)	2025			2024
Operating lease costs	$	15,127		$	15,637
Variable lease costs	8,656			7,724
Sublease income	1,068			—
Weighted-average remaining lease term (in years) - operating leases	15.18 years			15.21 years
Weighted-average discount rate - operating leases	6.49		%	6.52		%

Supplemental cash flow information related to leases are as follows:


	September 30,
(in thousands)	2025		2024
Cash payments included in the measurement of operating lease liabilities	$	14,853	$	14,707

Common Stock - Narrative (Details) shares in Thousands	12 Months Ended
Common Stock - Narrative (Details) shares in Thousands	Sep. 30, 2025 vote $ / shares shares	Feb. 28, 2025 $ / shares shares	Sep. 30, 2024 $ / shares shares
Equity [Abstract]
Common stock, par value (in dollars per share) \| $ / shares	$ 0.00001	$ 0.00001	$ 0.00001
Number of votes per share \| vote	1
Increase in authorized common stock (in shares) \| shares	200,000	200,000	100,000

Summary of Significant Accounting Policies - Cash and Cash Equivalents (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2022
Accounting Policies [Abstract]
Cash and cash equivalents	$ 183,049	$ 226,316
Restricted cash, non-current	2,376	2,816
Total cash, cash equivalents and restricted cash	$ 185,425	$ 229,132	$ 289,281	$ 380,259

Income Taxes - Components of Pre-tax Loss (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Income Tax Disclosure [Abstract]
US	$ (78,490)	$ (209,545)	$ (205,389)
Foreign	1,539	1,379	1,923
Loss before income taxes	$ (76,951)	$ (208,166)	$ (203,466)

- Definition

Amount of income (loss) from continuing operations, including income (loss) from equity method investments, before deduction of income tax expense (benefit), and income (loss) attributable to noncontrolling interest.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
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-Name Accounting Standards Codification
-Section 55
-Paragraph 4
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Reference 3: http://www.xbrl.org/2003/role/exampleRef
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2009/role/commonPracticeRef
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-URI https://asc.fasb.org/1943274/2147482810/280-10-50-22

Reference 7: http://www.xbrl.org/2003/role/exampleRef
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Reference 8: http://www.xbrl.org/2009/role/commonPracticeRef
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Reference 9: http://www.xbrl.org/2009/role/commonPracticeRef
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Reference 10: http://www.xbrl.org/2009/role/commonPracticeRef
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-SubTopic 10
-Name Accounting Standards Codification
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-Paragraph 1
-Subparagraph (i)
-Publisher FASB
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Reference 11: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 280
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-Name Accounting Standards Codification
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Reference 12: http://fasb.org/us-gaap/role/ref/otherTransitionRef
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-Paragraph 32
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-32

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 944
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-Name Accounting Standards Codification
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-Paragraph 1
-Subparagraph (SX 210.7-04(11))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477250/944-220-S99-1

Reference 14: http://www.xbrl.org/2003/role/exampleRef
-Topic 280
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Reference 15: http://fasb.org/us-gaap/role/ref/legacyRef
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+ Details

Consolidated Statements of Cash Flows - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Operating activities

Net loss

$ (77,670)

$ (208,726)

$ (204,618)

Adjustments to reconcile net loss to net cash used in operating activities

Depreciation and amortization expense

24,853

31,432

29,310

Impairment of long-lived assets

44,930

6,785

Non-cash lease expense, net of tenant improvement allowance

(20)

940

2,573

Stock-based compensation expense

64,459

50,925

30,278

Change in fair value of contingent considerations and holdbacks

(5,913)

Gain on sale of business

(48,847)

Other non-cash adjustments

2,203

994

120

Changes in assets and liabilities:

Accounts receivable, net

^[1]

(22,382)

8,444

(4,320)

Inventories

(4,229)

7,986

7,238

Prepaid expenses and other current assets

^[2]

(3,717)

382

(4,166)

Other non-current assets

(1,568)

431

1,376

Accounts payable

9,332

(11,805)

(2,508)

Accrued expenses

5,751

4,415

2,578

Accrued compensation

(2,405)

7,875

(1,099)

Other liabilities

^[3]

6,612

(2,317)

(108)

Net cash used in operating activities

(47,628)

(64,094)

(142,474)

Investing activities

Purchases of property and equipment

(28,004)

(5,076)

(27,779)

Purchases of investments

(49,393)

(51,905)

(76,345)

Proceeds from maturity of investments

50,135

53,910

154,736

Proceeds from sale of business

2,500

Net cash provided by (used in) investing activities

(24,762)

(3,071)

50,612

Financing activities

Proceeds from exercise of stock options

9,343

7,100

1,379

Proceeds from the issuance of liability related to sale of future revenue

15,000

Proceeds from issuance under employee stock purchase plan

4,213

3,765

3,937

Repurchases of common stock for income tax withholding

(16)

(3,975)

(4,405)

Net cash provided by financing activities

28,540

6,890

911

Effect of exchange rates on cash, cash equivalents and restricted cash

143

126

(27)

Net increase (decrease) in cash, cash equivalents and restricted cash

(43,707)

(60,149)

(90,978)

Cash, cash equivalents, and restricted cash at beginning of year

229,132

289,281

380,259

Cash, cash equivalents, and restricted cash at end of year

185,425

229,132

289,281

Supplemental disclosure of cash flow information

Income taxes paid, net of refunds

683

344

420

Non-cash investing and financing activities

Property and equipment additions included in accrued expenses and accounts payable

2,408

772

Operating lease right-of-use assets obtained in exchange for operating lease liabilities

6,676

Issuance of common stock in connection with the business acquisition

5,860

Tenant improvement allowance capitalized in property and equipment

2,719

Equity securities received as consideration for sale of business

53,890

Promissory note receivable received as consideration for sale of business

1,696

Conversion of convertible notes

$ 0

$ 3,711

[1]	Including changes in the related parties' balances of $(0.8) million, $1.2 million and $(1.7) million for the years ended September 30, 2025, 2024 and 2023, respectively.
[2]	Including changes in a related party balances of $(0.3) million, $— million and $— million for the years ended September 30, 2025, 2024 and 2023, respectively.
[3]	Including changes in a related party' balances of $0.2 million, $— million and $— million for the years ended September 30, 2025, 2024 and 2023, respectively.

Revenues - Revenues by Industry (Details) - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Segment Reporting Information [Line Items]

Revenues

^[1]

$ 376,572

$ 312,974

$ 245,109

Industrial chemicals/materials

Segment Reporting Information [Line Items]

Revenues

93,246

83,472

59,321

Academic research

Segment Reporting Information [Line Items]

Revenues

65,861

58,452

45,847

Healthcare

Segment Reporting Information [Line Items]

Revenues

215,092

168,959

137,148

Food/agriculture

Segment Reporting Information [Line Items]

Revenues

$ 2,373

$ 2,091

$ 2,793

[1]	Including revenues from related parties of $12.2 million, $12.1 million and $5.9 million during the year end September 30, 2025, 2024 and 2023, respectively.

- Definition

Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 41
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-41

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
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-Name Accounting Standards Codification
-Section 50
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-42

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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-Topic 280
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-Name Accounting Standards Codification
-Section 50
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-22

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
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-Section 50
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-URI https://asc.fasb.org/1943274/2147479806/606-10-50-4

+ Details

Leases

12 Months Ended

Sep. 30, 2025

Leases [Abstract]

Leases

The Company leases certain of its facilities under non-cancellable operating leases expiring at various dates through 2044. The Company is also responsible for utilities, maintenance, insurance, and property taxes under these leases. Our lease payments consist primarily of fixed rental payments for the right to use the underlying leased assets over the lease terms, as well as payments for common-area-maintenance and administrative services. We often receive customary incentives from our landlords, such as reimbursements for tenant improvements and rent abatement periods, which effectively reduce the total lease payments owed for these leases. Leases are classified as operating or financing at commencement. We do not have any material financing leases.

Certain leases include options to renew or terminate at the Company’s discretion. The lease terms include periods covered by these options if it is reasonably certain the Company will renew or not terminate. The Company’s lease agreements do not contain any material residual value guarantees or restrictive covenants.

As part of the sale of DNA data storage business, the Company subleased specific office and lab space to Atlas in South San Francisco (see note 6).

Future minimum lease payments and sublease income under all non-cancelable operating leases as of September 30, 2025 are as follows:


(in thousands)	Operating leases		Sublease income
Years ending September 30:
2026	$	13,963	$	1,918
2027	8,450		1,975
2028	8,510		2,035
2029	6,609		—
2030	6,787		—
Thereafter	74,618		—
Total minimum lease payments	$	118,937	$	5,928
Less: imputed interest	(43,365)
Total operating lease liabilities	$	75,572
Less: current portion	(13,822)
Operating lease liabilities, net of current portion	$	61,750

The components of lease expense and supplemental information were as follows:


	September 30,
(in thousands except years and percentage)	2025			2024
Operating lease costs	$	15,127		$	15,637
Variable lease costs	8,656			7,724
Sublease income	1,068			—
Weighted-average remaining lease term (in years) - operating leases	15.18 years			15.21 years
Weighted-average discount rate - operating leases	6.49		%	6.52		%

Supplemental cash flow information related to leases are as follows:


	September 30,
(in thousands)	2025		2024
Cash payments included in the measurement of operating lease liabilities	$	14,853	$	14,707

Consolidated Balance Sheets (Parenthetical) - USD ($)
shares in Thousands, $ in Thousands

Sep. 30, 2025

Sep. 30, 2024

Common stock, par value (in dollars per share)

$ 0.00001

Common stock, share authorized (in shares)

200,000

100,000

Common stock, share issued (in shares)

60,631

58,877

Common stock, outstanding (in shares)

60,631

58,877

Accounts receivable, net

^[1]

$ 57,019

$ 34,903

Prepaid expenses and other current assets

^[2]

15,204

11,396

Other non-current liabilities

^[3]

747

407

Investment in equity securities

^[4]

54,337

1,525

Related Party

Accounts receivable, net

1,300

500

Prepaid expenses and other current assets

300

Financing receivable, after allowance for credit loss, noncurrent

1,800

Other non-current liabilities

200

Investment in equity securities

$ 53,900

$ 0

[1]	Including related parties' balances of $1.3 million and $0.5 million as of September 30, 2025 and 2024, respectively.
[2]	Including related party balances of $0.3 million and $— million as of September 30, 2025 and 2024, respectively.
[3]	Including related party balances of $0.2 million and $— million as of September 30, 2025 and 2024, respectively.
[4]	Including related party balances of $53.9 million and $— million as of September 30, 2025 and 2024, respectively.

Cash, Cash Equivalent and Short-term Investments (Tables)

12 Months Ended

Sep. 30, 2025

Cash and Cash Equivalents [Abstract]

Summary of Debt Securities Available-for-Sale

The following table sets forth the cash and cash equivalents, and investments as of September 30, 2025:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash	$	32,677	$	—	$	—	$	32,677
Cash equivalents - money market funds	150,372		—		—		150,372
Total cash and cash equivalents	$	183,049	$	—	$	—	$	183,049
Short-term investments:
U.S. government treasury bills	$	49,316	$	69	$	—	$	49,385
Total short-term investments	$	49,316	$	69	$	—	$	49,385
Total cash, cash equivalents and short-term investments	$	232,365	$	69	$	—	$	232,434

The following table sets forth the cash and cash equivalents, and investments as of September 30, 2024:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash	$	26,458	$	—	$	—	$	26,458
Cash equivalents - money market funds	199,858		—		—		199,858
Total cash and cash equivalents	$	226,316	$	—	$	—	$	226,316
Short-term investments:
U.S. government treasury bills	$	49,964	$	119	$	—	$	50,083
Total short-term investments	$	49,964	$	119	$	—	$	50,083
Total cash, cash equivalents and short-term investments	$	276,280	$	119	$	—	$	276,399

Summary of Cash and Cash Equivalents


	September 30,
(in thousands)	2025		2024
Cash and cash equivalents	$	183,049	$	226,316
Restricted cash, non-current	2,376		2,816
Total cash, cash equivalents and restricted cash	$	185,425	$	229,132

The following table sets forth the cash and cash equivalents, and investments as of September 30, 2025:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash	$	32,677	$	—	$	—	$	32,677
Cash equivalents - money market funds	150,372		—		—		150,372
Total cash and cash equivalents	$	183,049	$	—	$	—	$	183,049
Short-term investments:
U.S. government treasury bills	$	49,316	$	69	$	—	$	49,385
Total short-term investments	$	49,316	$	69	$	—	$	49,385
Total cash, cash equivalents and short-term investments	$	232,365	$	69	$	—	$	232,434

The following table sets forth the cash and cash equivalents, and investments as of September 30, 2024:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash	$	26,458	$	—	$	—	$	26,458
Cash equivalents - money market funds	199,858		—		—		199,858
Total cash and cash equivalents	$	226,316	$	—	$	—	$	226,316
Short-term investments:
U.S. government treasury bills	$	49,964	$	119	$	—	$	50,083
Total short-term investments	$	49,964	$	119	$	—	$	50,083
Total cash, cash equivalents and short-term investments	$	276,280	$	119	$	—	$	276,399

- Definition

Tabular disclosure of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 9
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-9

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
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-Section 50
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-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef
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-Section 50
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-URI https://asc.fasb.org/1943274/2147481800/320-10-50-2

Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef
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-Name Accounting Standards Codification
-Section 50
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Reference 5: http://www.xbrl.org/2009/role/commonPracticeRef
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-Section 50
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Reference 6: http://www.xbrl.org/2009/role/commonPracticeRef
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Reference 7: http://www.xbrl.org/2009/role/commonPracticeRef
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Reference 8: http://www.xbrl.org/2009/role/commonPracticeRef
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Reference 9: http://www.xbrl.org/2009/role/commonPracticeRef
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Reference 10: http://www.xbrl.org/2009/role/commonPracticeRef
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

+ Details

Fair Value Measurement

12 Months Ended

Sep. 30, 2025

Fair Value Disclosures [Abstract]

Fair Value Measurement

The Company determines the fair value of financial and non-financial assets and liabilities using the fair value hierarchy which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. The standard describes three levels of inputs that may be used to measure fair value:

Level 1—Quoted prices in active markets for identical assets or liabilities.

Level 2—Observable inputs other than Level 1 prices such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

In determining fair value, the Company utilizes valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible as well as considering counterparty credit risk in its assessment of fair value.

Assets Measured at Fair Value on a Recurring Basis

As of September 30, 2025, financial assets measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	150,372	$	—	$	—	$	150,372
U.S. government treasury bills	49,385		—		—		49,385
Total financial assets	$	199,757	$	—	$	—	$	199,757

As of September 30, 2024, financial assets measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	199,858	$	—	$	—	$	199,858
U.S. government treasury bills	50,083		—		—		50,083
Total financial assets	$	249,941	$	—	$	—	$	249,941

Contractual maturities of short-term investments, as of September 30, 2025, were less than 12 months. The Company does not intend to sell the money market funds and short term investments and it is not more likely than not that the Company will be required to sell the investments before recovery of their amortized cost basis.

As of September 30, 2025 and 2024, there are no financial liabilities measured and recognized at fair value.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
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+ Details

Goodwill and Intangible Assets

12 Months Ended

Sep. 30, 2025

Goodwill and Intangible Assets Disclosure [Abstract]

Goodwill and Intangible Assets

Total amortization expense related to intangible assets was $1.1 million, $4.1 million, and $5.3 million for the years ended September 30, 2025, 2024 and 2023, respectively.

The goodwill balance is presented below:


	September 30,
(in thousands)	2025		2024
Balance at beginning of year	$	85,811	$	85,811
Sale of business (see note 6)	(3,616)		—
Balance at end of year	$	82,195	$	85,811

The finite-lived intangible assets balances are presented below:


	September 30, 2025
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Accumulated amortization		Net book value
Developed Technology	17	$	17,900	$	(4,475)	$	13,425
Total finite-lived intangible assets		$	17,900	$	(4,475)	$	13,425


	September 30, 2024
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Impairment		Accumulated amortization		Net book value
Developed Technology	17	$	50,020	$	(25,198)	$	(10,344)	$	14,478
Customer Relationships	—	15,210		(10,541)		(4,669)		—
Tradenames & Trademarks	—	900		(125)		(775)		—
Total finite-lived intangible assets		$	66,130	$	(35,864)	$	(15,788)	$	14,478

Future annual amortization expense is as follows (in thousands):


Years ending September 30,
2026	$	1,053
2027	1,053
2028	1,053
2029	1,053
2030	1,053
Thereafter	8,160
	$	13,425

Insider Trading Policies and Procedures	12 Months Ended
Insider Trading Policies and Procedures	Sep. 30, 2025
Insider Trading Policies and Procedures [Line Items]
Insider Trading Policies and Procedures Adopted	true

Stock-based Compensation - Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	$ 64,459	$ 50,925	$ 30,278
Cost of revenues
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	6,985	4,012	4,562
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	9,020	11,199	13,944
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	$ 48,454	$ 35,714	$ 11,772

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
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+ Details

Segment Information

12 Months Ended

Sep. 30, 2025

Segment Reporting [Abstract]

Segment Information

The Company’s Chief Executive Officer has been identified as the chief operating decision maker (CODM). The CODM reviews the Company’s operating results on a consolidated basis for purposes of allocating resources and evaluating financial performance. Specifically, the CODM evaluates the Company’s financial performance and decides how to allocate resources based on consolidated net income (loss), which enables the CODM to assess both the overall level of resources available and optimize distribution of resources across functions, product lines, regions and research and development programs in line with our long-term corporate-wide strategic goals. The CODM also reviews disaggregated revenue by product line, geographic regions, and industry (see Note 3).

The following table presents entity-wide significant expense categories and net loss details provided to the CODM:


	Year ended September 30,
(In thousands)	2025		2024		2023
Revenues	$	376,572	$	312,974	$	245,109
Costs and expenses:
Cost of revenues[1]	$	161,545	$	154,030	$	132,417
Research and development expenses[1]	69,950		76,605		88,937
Selling, general and administrative expenses[1]	192,024		175,883		171,070
Depreciation and amortization	24,853		31,432		29,310
Stock-based compensation expense	64,459		50,925		30,278
Restructuring and other costs	—		—		9,384
Change in fair value of contingent considerations and holdbacks	—		—		(5,913)
Impairment of long-lived assets	—		44,930		6,785
Total costs and expenses	$	512,831	$	533,805	$	462,268
Loss from operations	$	(136,259)	$	(220,831)	$	(217,159)
Gain on sale of business	$	48,847	$	—	$	—
Interest income	11,364		15,344		14,365
Other income (expense), net	(903)		(2,679)		(672)
Income (loss) before income taxes	$	(76,951)	$	(208,166)	$	(203,466)
Income tax expense	(719)		(560)		(1,152)
Net loss	$	(77,670)	$	(208,726)	$	(204,618)

[1] Excludes depreciation and amortization and stock-based compensation expense

Asset information is not regularly provided to the CODM for assessing performance and allocating resources other than consolidated cash and cash equivalents and short-term investments, which can be found on our Consolidated Balance Sheets.

- Definition

The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments.

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+ Details

Impairment of Long-lived Assets - Narrative (Details)	12 Months Ended
Impairment of Long-lived Assets - Narrative (Details)	Sep. 30, 2025
Restructuring and Related Activities [Abstract]
Intangible assets, Inherit risk percentage	0.14

Revenues - Revenues by Geographic Region (Details) - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Segment Reporting Information [Line Items]

Revenues

^[1]

$ 376,572

$ 312,974

$ 245,109

Americas

Segment Reporting Information [Line Items]

Revenues

225,580

193,884

151,263

EMEA

Segment Reporting Information [Line Items]

Revenues

124,240

92,567

71,389

APAC

Segment Reporting Information [Line Items]

Revenues

$ 26,752

$ 26,523

$ 22,457

[1]	Including revenues from related parties of $12.2 million, $12.1 million and $5.9 million during the year end September 30, 2025, 2024 and 2023, respectively.

- Definition

+ References

+ Details

Net Loss Per Share Attributable to Common Stockholders (Tables)

12 Months Ended

Sep. 30, 2025

Earnings Per Share [Abstract]

Summary of Computation of the Company's Basic and Diluted Net Loss Per Share Attributable to Common Stockholders

The following table sets forth the computation of the Company’s basic and diluted net loss per share attributable to common stockholders:


	Year ended September 30,
(in thousands, except per share data)	2025		2024		2023
Numerator:
Net loss attributable to common stockholders	$	(77,670)	$	(208,726)	$	(204,618)
Denominator:
Weighted-average shares used in computing net loss per share, basic and diluted	59,808		58,016		56,885
Net loss per share attributable to common stockholders, basic and diluted	$	(1.30)	$	(3.60)	$	(3.60)

Summary of Calculation of Diluted Net Loss Per Share

The potentially dilutive common shares that were excluded from the calculation of diluted net loss per share because their effect would have been antidilutive for the periods presented are as follows:


	Year ended September 30,
(in thousands)	2025	2024	2023
Shares subject to options to purchase common stock	1,276	1,891	2,408
Unvested restricted stock units and performance stock units	3,816	3,130	2,552
Shares subject to employee stock purchase plan	100	69	118
Total	5,192	5,090	5,078

Investment in Equity Securities (Tables)

12 Months Ended

Sep. 30, 2025

Discontinued Operations and Disposal Groups [Abstract]

Summary of Fair Value Measurement Inputs and Valuation Techniques

The following table lists the assumptions used to calculate the fair value of the investment:


	As of May 2, 2025
Discount for lack of marketability	10.0	%
Risk-free interest rate	3.8	%
Time of exit	3 years
Volatility	76.5	%

Summary of Disposal Groups, Including Discontinued Operations

The gain consists of the following assets transferred in accordance with the Contribution Agreement:


(in thousands)	As of May 2, 2025
Sale consideration:
Fair value of Series Seed-1 Preferred Stock	$	53,890
Fair value of promissory note receivable	1,696
Upfront cash consideration	2,500
	$	58,086
Net assets sold:
Property and equipment	$	(5,623)
Goodwill	(3,616)
	$	(9,239)
Gain on sale of business	$	48,847

- Definition

Tabular disclosure of information related to a disposal group. Includes, but is not limited to, a discontinued operation, disposal classified as held-for-sale or disposed of by means other than sale or disposal of an individually significant component.

+ References

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+ Details

Revenues - Narrative (Details) $ in Millions	12 Months Ended
Revenues - Narrative (Details) $ in Millions	Sep. 30, 2025 USD ($) investment	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)
Revenues from External Customers and Long-Lived Assets [Line Items]
Recognized revenue	$ 1.4	$ 1.7	$ 2.8
Performance obligation amount	$ 15.1
Customer One
Revenues from External Customers and Long-Lived Assets [Line Items]
Number of customer \| investment	1
Revenue from Contract with Customer Benchmark \| Customer Concentration Risk \| Customer One
Revenues from External Customers and Long-Lived Assets [Line Items]
Concentration risk, percentage	10.00%
United States \| Revenue from Contract with Customer Benchmark \| Geographic Concentration Risk
Revenues from External Customers and Long-Lived Assets [Line Items]
Concentration risk, percentage	58.00%	60.00%	60.00%

Liability Related to the Sales of Future Revenue	12 Months Ended
Liability Related to the Sales of Future Revenue	Sep. 30, 2025
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Liability Related to the Sales of Future Revenue	Liability Related to the Sales of Future Revenue On October 21, 2024, the Company executed the Royalty Purchase Agreement with XOMA (US) LLC ("XOMA Royalty"). Under the Royalty Purchase Agreement, XOMA Royalty provided Twist Bioscience an upfront payment of $15.0 million in cash in exchange for the right to receive half of the future potential milestone and royalty payments resulting from certain antibody discovery and biopharma services agreements between the Company and its customers ("underlying customer agreements"). The terms of the underlying customer agreements provide for milestone and royalty payments to the Company contingent upon the Company's customers achieving certain clinical, regulatory, development and commercial milestones. Under the terms of the underlying customer agreements, the Company has significant continuing involvement as the Company has ongoing obligations such as services to support the generation of these milestone and royalty payments. As such, the Company applied the guidance under ASC 470, Debt, and recorded the upfront payment of $15.0 million as a liability related to the sale of future revenue, which will be amortized using the effective interest method over the estimated term of the Royalty Purchase agreement. As milestone and royalty payments are remitted to XOMA Royalty, the balance of the liability related to the sale of future revenue will be effectively repaid over the term of the Royalty Purchase Agreement. In addition, in accordance with ASC 470, Debt, the Company will account for any milestone and royalty payments received in the future as revenue. The estimate of the effective interest rate contains significant assumptions regarding the timing and amount of expected milestone and royalty payments, which are considered Level 3 fair value inputs, and impact the interest expense that will be recognized over the term of the Royalty Purchase Agreement. As of September 30, 2025, the Company's estimate of aggregate future milestone and royalty payments expected to be paid to XOMA Royalty over the term of the Royalty Purchase Agreement did not exceed $15.0 million, therefore, no imputed interest expense has been recorded during the year ended September 30, 2025.

Stock-based Compensation - Activity Under the Equity Incentive Plans (Details) shares in Thousands	12 Months Ended
	Sep. 30, 2025 $ / shares shares
Restricted Stock Unit
Number of Shares
Non vested shares beginning balance (in shares) \| shares	1,964
Granted (in shares) \| shares	1,266
Vested/Issued (in shares) \| shares	(947)
Forfeited (in shares) \| shares	(401)
Non vested shares ending balance (in shares) \| shares	1,882
Weighted average grant date fair value per share
Weighted average grant date fair value, beginning balance (in dollars per share) \| $ / shares	$ 32.13
Granted (in dollars per share) \| $ / shares	45.75
Vested/ Issued (in dollars per share) \| $ / shares	39.12
Forfeited (in dollars per share) \| $ / shares	34.74
Weighted average grant date fair value, ending balance (in dollars per share) \| $ / shares	$ 37.21
Performance Stock Unit
Number of Shares
Non vested shares beginning balance (in shares) \| shares	1,166
Granted (in shares) \| shares	1,422
Vested/Issued (in shares) \| shares	(311)
Forfeited (in shares) \| shares	(343)
Non vested shares ending balance (in shares) \| shares	1,934
Weighted average grant date fair value per share
Weighted average grant date fair value, beginning balance (in dollars per share) \| $ / shares	$ 27.01
Granted (in dollars per share) \| $ / shares	47.07
Vested/ Issued (in dollars per share) \| $ / shares	44.90
Forfeited (in dollars per share) \| $ / shares	32.82
Weighted average grant date fair value, ending balance (in dollars per share) \| $ / shares	$ 37.85

Summary of Significant Accounting Policies - Estimated Lives of Property And Equipment (Details)	Sep. 30, 2025
Laboratory equipment
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Property, plant and equipment, useful life	5 years
Furniture, fixtures and other equipment
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Property, plant and equipment, useful life	5 years
Computer equipment
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Property, plant and equipment, useful life	3 years
Vehicles
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Property, plant and equipment, useful life	5 years
Computer software
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Property, plant and equipment, useful life	3 years

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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+ Details

Stock-based Compensation - Narrative (Details)		1 Months Ended	3 Months Ended	12 Months Ended
Stock-based Compensation - Narrative (Details)	Sep. 26, 2018 shares	Feb. 28, 2025 shares	Sep. 30, 2025 USD ($) shares	Sep. 30, 2025 USD ($) shares	Sep. 30, 2024 USD ($) shares	Sep. 30, 2023 USD ($)	Aug. 22, 2023 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Additional shares authorized (in shares) \| shares				249,000
Aggregate number of common stock shares reserved for issuance (in shares) \| shares			716,000	716,000	611,000
Capitalized computer software, net			$ 3,200,000	$ 3,200,000	$ 5,200,000
Share-based liabilities settled						$ 5,900,000
Total stock-based compensation expense				$ 64,459,000	50,925,000	30,278,000
Employer matching percentage				50.00%
Percentage of employee's gross pay matched				6.00%
Employer matching contributions				$ 3,000,000.0	2,600,000
Share-based Payment Arrangement
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Capitalized computer software, net			1,300,000	$ 1,300,000	1,300,000
Restricted Stock Unit
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period				4 years
Conversion ratio				1
Unrecognized compensation cost			64,800,000	$ 64,800,000
Recognize cost weighted average period				2 years 8 months 12 days
Grant date fair value				$ 57,900,000	42,700,000	32,200,000
Vested in period, fair value				$ 37,000,000	31,000,000	33,700,000
Restricted Stock Unit \| Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period				1 year
Performance Stock Unit
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost			$ 37,800,000	$ 37,800,000
Recognize cost weighted average period				1 year 7 months 6 days
Grant date fair value				$ 66,900,000	11,500,000	21,200,000
Vested in period, fair value				$ 14,000,000	6,900,000	1,800,000
Performance Stock Unit \| Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of PSUs that may vest based on performance				0.00%
Performance Stock Unit \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of PSUs that may vest based on performance				140.00%
Performance Stock Unit \| Employee \| Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period			10 months
Performance Stock Unit \| Employee \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period				34 months
Option
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period				4 years
Unrecognized compensation cost			$ 0	$ 0
Recognize cost weighted average period				2 months 12 days
Award term				10 years
Expected dividend yield				0.00%
Exercises in period, intrinsic value					9,200,000	1,100,000
2018 Equity Incentive Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Additional shares authorized (in shares) \| shares		3,700,000
Maximum aggregate number of shares (in shares) \| shares	10,068,911
Aggregate number of common stock shares reserved for issuance (in shares) \| shares			5,260,083	5,260,083
Inducement Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Additional shares authorized (in shares) \| shares		700,000
Maximum aggregate number of shares (in shares) \| shares							1,400,000
2018 ESPP
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Aggregate number of common stock shares reserved for issuance (in shares) \| shares	275,225
Minimum annual increase in share reserved for issuance \| shares	249,470
Annual automatic Increase in share reserved for issuance	1.00%
Percentage of payroll deduction to purchase common stock	15.00%
ESPP eligible employee common stock purchase price ratio	85.00%
2018 ESPP \| Shares subject to options to purchase common stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense				$ 2,400,000	$ 1,600,000	$ 0

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Sep. 30, 2025
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false

Balance Sheet Components - Other Current Liabilities (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Balance Sheet Related Disclosures [Abstract]
Income and other taxes payable	$ 4,543	$ 2,725
Contract liabilities	6,884	2,131
Other current liabilities	722	961
Other current liabilities	$ 12,149	$ 5,817

Segment Information - Segment Reporting Information, by Segment (Details) - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Segment Reporting Information [Line Items]

Revenues

^[1]

$ 376,572

$ 312,974

$ 245,109

Cost of revenues

185,570

179,625

155,380

Depreciation and amortization expense

24,853

31,432

29,310

Total stock-based compensation expense

64,459

50,925

30,278

Restructuring and other costs

9,384

Change in fair value of contingent considerations and holdbacks

(5,913)

Impairment of long-lived assets

44,930

6,785

Total costs and expenses

512,831

533,805

462,268

Loss from operations

(136,259)

(220,831)

(217,159)

Gain on sale of business

48,847

Interest income

11,364

15,344

14,365

Other income (expense), net

^[2]

(903)

(2,679)

(672)

Loss before income taxes

(76,951)

(208,166)

(203,466)

Income tax expense

(719)

(560)

(1,152)

Net loss attributable to common stockholders

(77,670)

(208,726)

(204,618)

Reportable Segment

Segment Reporting Information [Line Items]

Revenues

376,572

312,974

245,109

Cost of revenues

161,545

154,030

132,417

Research and development expenses

69,950

76,605

88,937

Selling, general and administrative expenses

192,024

175,883

171,070

Depreciation and amortization expense

24,853

31,432

29,310

Total stock-based compensation expense

64,459

50,925

30,278

Restructuring and other costs

9,384

Change in fair value of contingent considerations and holdbacks

(5,913)

Impairment of long-lived assets

44,930

6,785

Total costs and expenses

512,831

533,805

462,268

Loss from operations

(136,259)

(220,831)

(217,159)

Gain on sale of business

48,847

Interest income

11,364

15,344

14,365

Other income (expense), net

(903)

(2,679)

(672)

Loss before income taxes

(76,951)

(208,166)

(203,466)

Income tax expense

(719)

(560)

(1,152)

Net loss attributable to common stockholders

$ (77,670)

$ (208,726)

$ (204,618)

[1]	Including revenues from related parties of $12.2 million, $12.1 million and $5.9 million during the year end September 30, 2025, 2024 and 2023, respectively.
[2]	Including sublease income from a related party of $1.1 million, $— million and $— million during the year end September 30, 2025, 2024 and 2023, respectively.

Net Loss Per Share Attributable to Common Stockholders - Computation of the Company’s Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Numerator:
Net loss attributable to common stockholders	$ (77,670)	$ (208,726)	$ (204,618)
Denominator:
Weighted-average shares used in computing net loss per share, basic (in shares)	59,808,000	58,016,000	56,885,000
Weighted-average shares used in computing net loss per share, diluted (in shares)	59,808,000	58,016,000	56,885,000
Net loss per share attributable to common stockholders—basic (in dollars per share)	$ (1.30)	$ (3.60)	$ (3.60)
Net loss per share attributable to common stockholders—diluted (in dollars per share)	$ (1.30)	$ (3.60)	$ (3.60)

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147480097/470-10-S99-1B

Reference 43: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 60B
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482689/260-10-45-60B

Reference 44: http://www.xbrl.org/2003/role/disclosureRef
-Topic 205
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 7
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483499/205-20-50-7

Reference 45: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 230
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 28
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482740/230-10-45-28

Reference 46: http://www.xbrl.org/2003/role/disclosureRef
-Topic 220
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 1A
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482790/220-10-45-1A

Reference 47: http://www.xbrl.org/2003/role/disclosureRef
-Topic 220
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 1B
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482790/220-10-45-1B

Reference 48: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
-Section 65
-Paragraph 4
-Subparagraph (f)(4)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481538/470-20-65-4

Reference 49: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 942
-SubTopic 220
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(22))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478524/942-220-S99-1

+ Details

Impairment of Long-lived Assets - Impairment of Long-Lived Assets Held and Used (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Restructuring and Related Activities [Abstract]
Property and equipment		$ 9,066	$ 6,785
Finite-lived intangible assets	$ 4,475	35,864	0
Total	$ 0	$ 44,930	$ 6,785

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Sep. 30, 2025

Accounting Policies [Abstract]

Summary of Cash and Cash Equivalents


	September 30,
(in thousands)	2025		2024
Cash and cash equivalents	$	183,049	$	226,316
Restricted cash, non-current	2,376		2,816
Total cash, cash equivalents and restricted cash	$	185,425	$	229,132

The following table sets forth the cash and cash equivalents, and investments as of September 30, 2025:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash	$	32,677	$	—	$	—	$	32,677
Cash equivalents - money market funds	150,372		—		—		150,372
Total cash and cash equivalents	$	183,049	$	—	$	—	$	183,049
Short-term investments:
U.S. government treasury bills	$	49,316	$	69	$	—	$	49,385
Total short-term investments	$	49,316	$	69	$	—	$	49,385
Total cash, cash equivalents and short-term investments	$	232,365	$	69	$	—	$	232,434

The following table sets forth the cash and cash equivalents, and investments as of September 30, 2024:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash	$	26,458	$	—	$	—	$	26,458
Cash equivalents - money market funds	199,858		—		—		199,858
Total cash and cash equivalents	$	226,316	$	—	$	—	$	226,316
Short-term investments:
U.S. government treasury bills	$	49,964	$	119	$	—	$	50,083
Total short-term investments	$	49,964	$	119	$	—	$	50,083
Total cash, cash equivalents and short-term investments	$	276,280	$	119	$	—	$	276,399

Summary of Restrictions on Cash and Cash Equivalents


	September 30,
(in thousands)	2025		2024
Cash and cash equivalents	$	183,049	$	226,316
Restricted cash, non-current	2,376		2,816
Total cash, cash equivalents and restricted cash	$	185,425	$	229,132

Summary of Estimated Lives of Property And Equipment

Estimated lives of property and equipment are as follows:


Laboratory equipment			5 Years
Furniture, fixtures and other equipment			5 Years
Computer equipment			3 Years
Vehicles			5 Years
Computer software			3 Years
Leasehold improvements			Lesser of useful life or lease term

Impairment of Long-lived Assets

12 Months Ended

Sep. 30, 2025

Restructuring and Related Activities [Abstract]

Impairment of Long-lived Assets

On June 30, 2024, the Company identified an impairment indicator with respect to an asset group associated with our antibody discovery services product line (“Biopharma asset group”) due to lower than forecasted revenues. Therefore, the Company performed a recoverability test of long-lived assets by comparing the Biopharma asset group's net book value to its future undiscounted net cash flows. The Company concluded that the carrying value of the Biopharma asset group was not recoverable as it exceeded the future undiscounted cash flows the assets are expected to generate from their use and eventual disposition.

To measure the impairment loss, the Company estimated the fair value of the Biopharma asset group by applying a discounted cash flow method. In applying the discounted cash flow method, the Company made certain estimates and assumptions including, among others, the level and timing of revenues, operating expenses, working capital and discount rate. The Company used a discount rate of approximately 14%, which considers the inherent risks associated with the Biopharma asset group.

The allocated impairment loss to any individual long-lived asset within the long-lived asset group cannot reduce the carrying amount of that long-lived asset below its fair value. Accordingly, the Company determined the fair value of the long-lived assets within the Biopharma asset group based on their highest and best use. These assets include intangible assets, property and equipment, and right-of use assets. The Company estimated the fair value of the developed technology intangible asset and the customer relationships intangible asset using an excess earnings model (income approach). The Company estimated the fair value of the trade name intangible asset using a relief from royalty approach. In applying these valuation methods to the intangible assets, the Company made certain estimates and assumptions including the level and timing of expected cash flows and discount rate, which is consistent with the 14% discount rate noted above. The Company determined the fair value of property and equipment based on a market approach. The Company determined the fair value of the lease right-of-use assets by applying a present value technique to the estimated market rate rental cash flows.

Assumptions used to determine the fair values of certain lease right-of-use assets included estimated market rent and the discount rate.

These fair value measurements were based on significant inputs not observable in the market and thus represent a Level 3 measurement. The Company believes the level and timing of expected future cash flows appropriately reflects market participant assumptions.

As a result of allocating the impairment, the Company recorded an impairment charges, which was included in “Impairment of long-lived assets” on our consolidated statements of operations and comprehensive loss for the year ended September 30, 2024.

The impairment charges recorded for the year ended September 30, 2024 and September 30, 2023 are as follows:


	Year ended September 30,
(in thousands)	2024		2023
Property and equipment	$	9,066	$	6,785
Finite-lived intangible assets	35,864		—
Total	$	44,930	$	6,785

No impairment charges were recorded for the year ended September 30, 2025.

Common Stock	12 Months Ended
Common Stock	Sep. 30, 2025
Equity [Abstract]
Common Stock	Common Stock As of September 30, 2025, the Company had reserved sufficient shares of common stock with a par value of $0.00001 per share for issuance upon exercise of outstanding stock options. Each share of common stock is entitled to one vote. The holders of shares of common stock are also entitled to receive dividends whenever funds are legally available and when declared by the board of directors. In February 2025, the Company amended its Amended and Restated Certificate of Incorporation to provide for an increase in its authorized share capital. The authorized common stock increased to 200.0 million shares at a par value of $0.00001 per share.

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 8A
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480434/815-10-50-8A

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-14

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 235
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477968/946-235-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 235
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477968/946-235-50-2

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 505
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478448/946-505-50-6

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480237/815-40-50-6

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480008/505-10-S99-1

Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 505
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org/505/tableOfContent

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (g)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (i)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-14

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-14

Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 16
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-16

Reference 17: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 18
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-18

Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 18
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-18

Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 18
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-18

+ Details

Stock-based Compensation - Stock Option Activity (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
Shares
Number of options, Outstanding beginning balance (in shares)	1,892
Forfeited (in shares)	(132)
Exercised (in shares)	(484)
Number of options, Outstanding ending balance (in shares)	1,276	1,892
Number of options, Exercisable (in shares)	1,275
Weighted average exercise price per share
Weighted average exercise price per share, Outstanding beginning balance (in dollars per share)	$ 29.60
Forfeited (in dollars per share)	55.78
Exercised (in dollars per share)	19.31
Weighted average exercise price per share, Outstanding ending balance (in dollars per share)	30.80	$ 29.60
Weighted average exercise price per share, Exercisable (in dollars per share)	$ 30.79
Weighted average remaining contractual term (years)
Weighted average remaining contractual term (years)	3 years 7 months 2 days	4 years 6 months 25 days
Weighted average remaining contractual term (years), Exercisable	3 years 7 months 2 days
Aggregate intrinsic value
Aggregate intrinsic value, outstanding beginning balance	$ 37,840
Aggregate intrinsic value, Exercised	10,571
Aggregate intrinsic value, outstanding ending balance	6,616	$ 37,840
Aggregate intrinsic value, exercisable	$ 6,616

Stock-based Compensation - Reserved For Issuance (Details) shares in Thousands	12 Months Ended
	Sep. 30, 2025 shares
Number Of Shares Reserved For Issuance [Roll Forward]
As of at September 30, 2024 (in shares)	611
Additional shares authorized (in shares)	249
Shares issued during the period (in shares)	(144)
As of at September 30, 2025 (in shares)	716

Net Loss Per Share Attributable to Common Stockholders

12 Months Ended

Sep. 30, 2025

Earnings Per Share [Abstract]

Net Loss Per Share Attributable to Common Stockholders

The following table sets forth the computation of the Company’s basic and diluted net loss per share attributable to common stockholders:


	Year ended September 30,
(in thousands, except per share data)	2025		2024		2023
Numerator:
Net loss attributable to common stockholders	$	(77,670)	$	(208,726)	$	(204,618)
Denominator:
Weighted-average shares used in computing net loss per share, basic and diluted	59,808		58,016		56,885
Net loss per share attributable to common stockholders, basic and diluted	$	(1.30)	$	(3.60)	$	(3.60)


	Year ended September 30,
(in thousands)	2025	2024	2023
Shares subject to options to purchase common stock	1,276	1,891	2,408
Unvested restricted stock units and performance stock units	3,816	3,130	2,552
Shares subject to employee stock purchase plan	100	69	118
Total	5,192	5,090	5,078

Consolidated Statements of Operations and Comprehensive Loss (Parenthetical) - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Revenues

^[1]

$ 376,572

$ 312,974

$ 245,109

Sublease income

1,068

Related Party

Revenues

12,200

12,100

5,900

Sublease income

$ 1,100

$ 0

[1]	Including revenues from related parties of $12.2 million, $12.1 million and $5.9 million during the year end September 30, 2025, 2024 and 2023, respectively.

- Definition

+ References

+ Details

Leases - Components of Lease Expense and Supplemental Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
Leases [Abstract]
Operating lease costs	$ 15,127	$ 15,637
Variable lease costs	8,656	7,724
Sublease income	$ 1,068	$ 0
Weighted-average remaining lease term (in years) - operating leases	15 years 2 months 4 days	15 years 2 months 15 days
Weighted-average discount rate - operating leases	6.49%	6.52%

Consolidated Balance Sheets - USD ($)
$ in Thousands

Sep. 30, 2025

Sep. 30, 2024

Current assets:

Cash and cash equivalents

$ 183,049

$ 226,316

Short-term investments

49,385

50,083

Accounts receivable, net

^[1]

57,019

34,903

Inventories

28,309

24,078

Prepaid expenses and other current assets

^[2]

15,204

11,396

Total current assets

332,966

346,776

Property and equipment, net

102,283

102,520

Operating lease right-of-use assets

49,377

58,829

Investment in equity securities

^[3]

54,337

1,525

Goodwill

82,195

85,811

Intangible assets, net

13,425

14,478

Restricted cash, non-current

2,376

2,816

Other non-current assets

^[4]

4,902

1,568

Total assets

641,861

614,323

Current liabilities:

Accounts payable

11,094

1,630

Accrued expenses

23,053

15,104

Accrued compensation

31,288

33,650

Current portion of operating lease liability

13,822

14,805

Other current liabilities

12,149

5,817

Total current liabilities

91,406

71,006

Operating lease liability, net of current portion

61,750

70,221

15,000

Other non-current liabilities

^[5]

747

407

Total liabilities

168,903

141,634

Commitments and contingencies

Stockholders’ equity

Common stock, $0.00001 par value — 200,000 and 100,000 shares authorized at September 30, 2025 and 2024, respectively; 60,631 and 58,877 shares issued and outstanding at September 30, 2025 and 2024, respectively

Additional paid-in capital

1,793,163

1,715,119

Accumulated other comprehensive loss

(627)

(522)

Accumulated deficit

(1,319,578)

(1,241,908)

Total stockholders’ equity

472,958

472,689

Total liabilities and stockholders’ equity

$ 641,861

$ 614,323

[1]	Including related parties' balances of $1.3 million and $0.5 million as of September 30, 2025 and 2024, respectively.
[2]	Including related party balances of $0.3 million and $— million as of September 30, 2025 and 2024, respectively.
[3]	Including related party balances of $53.9 million and $— million as of September 30, 2025 and 2024, respectively.
[4]	Including related party balances of $1.8 million and $— million as of September 30, 2025 and 2024, respectively.
[5]	Including related party balances of $0.2 million and $— million as of September 30, 2025 and 2024, respectively.

Commitments and Contingencies	12 Months Ended
Commitments and Contingencies	Sep. 30, 2025
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Legal Proceedings The Company may be subject to litigation, claims and disputes in the ordinary course of business. Certain significant matters are described below. We recognize accruals for matters to the extent that we conclude that a loss is both probable and reasonably estimable. If we determine that a material loss is reasonably possible and the loss or range of loss can be estimated, we disclose the possible loss. Securities Class Action On December 12, 2022, a putative securities class action lawsuit captioned Peters v. Twist Bioscience Corporation, et al., Case No. 22-cv-08168 (N.D. Cal.) (“Securities Class Action”) was filed in federal court in the Northern District of California (“Court”) against the Company, its Chief Executive Officer, and its Chief Financial Officer (the “Defendants”) alleging violations of federal securities laws. The Securities Class Action’s claims are based in large part on allegations made in a report issued on November 15, 2022 by Scorpion Capital (“Scorpion Report”) concerning, among other things, the Company’s DNA chip technology and accounting practices. The initial complaint filed in the Securities Class Action alleges that various statements that the Defendants made between December 13, 2019 and November 14, 2022 were materially false and misleading in light of the allegations in the Scorpion Report. The plaintiff who initiated the lawsuit sought to represent a class of shareholders who acquired shares of the Company’s common stock between December 13, 2019 and November 14, 2022 and sought damages as well as certain other costs. On July 28, 2023, the Court appointed a new plaintiff, not the original plaintiff who filed the case, as lead plaintiff in the case and appointed a new law firm as lead counsel. On October 11, 2023, the lead plaintiff filed an amended complaint. The amended complaint is purportedly brought on behalf of all persons other than the Defendants who acquired the Company’s securities between December 20, 2018 and November 15, 2022. The amended complaint alleges that certain statements regarding, among other things, the Company’s DNA products and accounting practices were false and misleading. On December 6, 2023, the Company filed a motion to dismiss the amended complaint and a hearing on the motion to dismiss was held on November 13, 2024. On September 3, 2025, the Court issued an order granting in part and denying in part Defendants’ motion to dismiss and granted the plaintiff leave to further amend by September 24, 2025. The plaintiff did not file a second amended complaint. The Company is engaged in discovery and intends to continue vigorously defending the remaining claims under this action in all respects. Given the inherent uncertainty of litigation and the legal standards that must be met, including class certification and success on the merits, the Company cannot express an opinion on the likelihood of an unfavorable outcome or on the amount or range of any potential loss. Derivative Action On September 25, 2023, a shareholder derivative suit captioned Shumacher vs. Leproust et al., No. 1:23-cv-01048-UNA, was filed in the United States District Court for the District of Delaware against directors of the Company and an employee (the “Derivative Action”). The suit is based on substantially the same allegations in the Securities Class Action and seeks to recover, on behalf of the Company, damages to the Company arising from, among other things, the Securities Class Action. On November 13, 2023, the parties to the Derivative Action entered into a stipulation staying the Derivative Action pending resolution of the anticipated motion to dismiss the defendants have filed in the Securities Class Action. Indemnifications In the ordinary course of business, the Company enters into agreements that may include indemnification provisions. Pursuant to such agreements, the Company may indemnify, hold harmless and defend the indemnified parties for losses suffered or incurred by the indemnified party. Some of the provisions will limit losses to those arising from third-party actions. In some cases, the indemnification will continue after the termination of the agreement. The maximum potential amount of future payments the Company could be required to make under these provisions is not determinable. To date, the Company has not incurred material costs to defend lawsuits or settle claims related to these indemnification provisions. From time to time, the Company has entered into indemnification agreements with its directors and officers that requires it to indemnify its directors and officers against liabilities that may arise by reason of their status or service as directors or officers to the fullest extent permitted by law. The Company also has directors’ and officers’ insurance.

Investment in Equity Securities

12 Months Ended

Sep. 30, 2025

Discontinued Operations and Disposal Groups [Abstract]

Investment in Equity Securities

On May 2, 2025, the Company executed and consummated the Contribution Agreement with Atlas for the sale and transfer of its DNA digital data storage assets, including the related intellectual property, equipment and contracts and the license of certain other intellectual property for a consideration of 73.0 million shares of Series Seed-1 Preferred Stock of Atlas, upfront cash consideration of $2.5 million, promissory notes of $2.0 million, contingent manufacturing and commercial milestone payments of up to $75.0 million, and royalty payments based on a percentage of Atlas sales of the DNA data storage products or services. As part of this transaction, certain employees of the Company were transitioned to Atlas.

The Company concluded that its investment in shares of preferred stock of Atlas are not in substance common stock and accounted for the investment at fair value at its acquisition date of $53.9 million. The Company measured the fair value of our investment in Series Seed-1 Preferred Stock of Atlas using the backsolve method with consideration for a lack of marketability. The backsolve method was used to solve for the implied total equity value based on the recent Series Seed financing round by Atlas to third-party investors. Consideration was given to the rights and preferences of each of the classes of equity of Atlas and the expected time to a liquidity event. An option pricing allocation method, or OPM, was selected to allocate the total equity value. The following table lists the assumptions used to calculate the fair value of the investment:


	As of May 2, 2025
Discount for lack of marketability	10.0	%
Risk-free interest rate	3.8	%
Time of exit	3 years
Volatility	76.5	%

Subsequent to the acquisition date, the Company elected to account for its investment in the preferred stock of Atlas using the measurement alternative method since Atlas is a private company, these securities do not have readily determinable fair value.

The promissory notes are secured by the patents owned by Atlas and any income and royalties from such patents. The promissory note together with accrued interest at an interest rate of 4% per annum, is payable on the earliest of: (i) at Atlas' election, on or after December 31, 2028, (ii) the closing of the issuance and sale of

shares of common stock in Atlas' first underwritten public offering, (iii) the 10 year anniversary from May 2, 2025, or (iv) Atlas’ insolvency, dissolution, or bankruptcy.

The Company accounted for the promissory note receivable at its fair value of $1.7 million and recognized immaterial interest income on the promissory notes during the year ended September 30, 2025. Promissory note receivable is carried at amortized cost and reduced by a valuation allowance for estimated credit losses, as necessary. The Company recognizes interest income on loans, including the amortization of discounts and premiums, using the effective interest method. As of September 30, 2025, the carrying value of the promissory note receivable is $1.8 million.

The sale of DNA digital data storage assets to Atlas constitutes a disposition of a business. The Company concluded the disposition does not represent a strategic shift, and therefore, the Company has not accounted for the disposition as a discontinued operation. The Company recorded a $48.8 million gain on sale of business on the consolidated statements of operations and comprehensive income (loss) for the year ended September 30, 2025. The Company allocated goodwill to the DNA Data Storage business disposed and the remaining business based on their relative fair values. The gain consists of the following assets transferred in accordance with the Contribution Agreement:


(in thousands)	As of May 2, 2025
Sale consideration:
Fair value of Series Seed-1 Preferred Stock	$	53,890
Fair value of promissory note receivable	1,696
Upfront cash consideration	2,500
	$	58,086
Net assets sold:
Property and equipment	$	(5,623)
Goodwill	(3,616)
	$	(9,239)
Gain on sale of business	$	48,847

The Company concluded that Atlas is a variable interest entity. While the Company holds one of the seven board of director seats in Atlas, the Company does not have the power, whether through contractual relationships or other factors, to direct the activities that most significantly impact the economic performance of Atlas. Therefore, the Company concluded it is not its primary beneficiary. The Company’s maximum exposure to loss from this VIE consist of investment in equity securities, promissory note receivable and other receivables for amounts billed under the transition services agreement and the sublease agreement aggregating to $56.0 million. There were no impairments during the year ended September 30, 2025.

The Company agreed to provide transitional support services to Atlas in the areas of accounting, payroll, and IT in return for payment on a time and material basis to Atlas in furtherance of its obligations under the Transition Services Agreement ("TSA") executed as part of the Contribution Agreement. The TSA also provides for continued access to relevant systems and other relevant premises on a transitional basis and reimbursement of third-party vendor costs for procurement of goods and services on behalf of Atlas. The Company's obligations under the TSA are expected to be completed within a year from the transaction date.

Further, as part of the Contribution Agreement, the Company subleased specific office and lab space to Atlas in South San Francisco (see note 11).

The Company holds an equity investment in another privately held company which is accounted for as an equity security without a readily determinable fair value using a measurement alternative. The privately held company is a VIE, but the Company is not the primary beneficiary. The Company does not have the power to direct the activities that most significantly impact the economic performance of the investee. The Company’s maximum exposure to loss from this VIE consist of an equity investment of $0.4 million. The Company impaired $1.1 million and $2.2 million during the year ended September 30, 2025 and September 30, 2024, respectively.

Audit Information	12 Months Ended
Audit Information	Sep. 30, 2025
Audit Information [Abstract]
Auditor Firm ID	42
Auditor Name	Ernst & Young LLP
Auditor Location	San Mateo, California

Related Party Transactions (Details) - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Raw materials purchased from related party investor

$ 0

$ 4,400

$ 6,800

Revenues (less than in 2025)

^[1]

376,572

312,974

245,109

Accounts payable

11,094

1,630

Accounts receivable, net

^[2]

57,019

34,903

Sublease income

1,068

Investment in equity securities

^[3]

54,337

1,525

Prepaid expenses and other current assets

^[4]

15,204

11,396

Interest income

Other non-current liabilities

^[5]

747

407

Revenues (less than in 2025)

12,200

12,100

5,900

Accounts payable

Accounts receivable, net

1,300

500

Sublease income

1,100

$ 0

Investment in equity securities

53,900

Prepaid expenses and other current assets

300

Financing receivable, after allowance for credit loss, noncurrent

1,800

Other non-current liabilities

200

$ 0

Related Party | Atlas Data Storage, Inc

Revenues (less than in 2025)

$ 100

[1]	Including revenues from related parties of $12.2 million, $12.1 million and $5.9 million during the year end September 30, 2025, 2024 and 2023, respectively.
[2]	Including related parties' balances of $1.3 million and $0.5 million as of September 30, 2025 and 2024, respectively.
[3]	Including related party balances of $53.9 million and $— million as of September 30, 2025 and 2024, respectively.
[4]	Including related party balances of $0.3 million and $— million as of September 30, 2025 and 2024, respectively.
[5]	Including related party balances of $0.2 million and $— million as of September 30, 2025 and 2024, respectively.

Revenues - Contract Balances (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Revenue from Contract with Customer [Abstract]
Contract assets	$ 3,857	$ 2,031
Contract liabilities	$ 6,884	$ 2,131

Fair Value Measurement - Company's Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Assets
Short term investments, fair value	$ 49,385	$ 50,083
Total financial assets	199,757	249,941
U.S. government treasury bills
Assets
Short term investments, fair value	49,385	50,083
Money market funds
Assets
Money market funds	150,372	199,858
Level 1
Assets
Total financial assets	199,757	249,941
Level 1 \| U.S. government treasury bills
Assets
Short term investments, fair value	49,385	50,083
Level 1 \| Money market funds
Assets
Money market funds	150,372	199,858
Level 2
Assets
Total financial assets	0	0
Level 2 \| U.S. government treasury bills
Assets
Short term investments, fair value	0	0
Level 2 \| Money market funds
Assets
Money market funds	0	0
Level 3
Assets
Total financial assets	0	0
Level 3 \| U.S. government treasury bills
Assets
Short term investments, fair value	0	0
Level 3 \| Money market funds
Assets
Money market funds	$ 0	$ 0

- Definition

Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (bbb)(2)(i)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482106/820-10-50-2

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (bbb)(2)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482106/820-10-50-2

Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 820
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-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (bbb)(1)
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-URI https://asc.fasb.org/1943274/2147482106/820-10-50-2

Reference 4: http://www.xbrl.org/2003/role/exampleRef
-Name Accounting Standards Codification
-Section 55
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 825
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-Name Accounting Standards Codification
-Section 45
-Paragraph 1A
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482736/825-10-45-1A

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 825
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-Name Accounting Standards Codification
-Section 50
-Paragraph 11
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482907/825-10-50-11

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 825
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-Name Accounting Standards Codification
-Section 50
-Paragraph 11
-Subparagraph (a)
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-URI https://asc.fasb.org/1943274/2147482907/825-10-50-11

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 825
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 10
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482907/825-10-50-10

Reference 9: http://www.xbrl.org/2003/role/exampleRef
-Topic 825
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 12
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482881/825-10-55-12

Reference 10: http://www.xbrl.org/2003/role/exampleRef
-Topic 820
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-Name Accounting Standards Codification
-Section 55
-Paragraph 103
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482078/820-10-55-103

Reference 11: http://www.xbrl.org/2003/role/exampleRef
-Topic 820
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-Name Accounting Standards Codification
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
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-URI https://asc.fasb.org/1943274/2147482106/820-10-50-2

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
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-Name Accounting Standards Codification
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-Paragraph 2
-Subparagraph (aa)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-2

Reference 14: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
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-Name Accounting Standards Codification
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-Paragraph 1
-Subparagraph (b)
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-URI https://asc.fasb.org/1943274/2147481830/320-10-45-1

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Topic 942
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-Name Accounting Standards Codification
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-Paragraph 1
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 326
-SubTopic 30
-Name Accounting Standards Codification
-Section 45
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479130/326-30-45-1

+ Details

Income Taxes - Unrecognized Tax Benefits Roll Forward (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Unrecognized Tax Benefits [Roll Forward]
Unrecognized tax benefits at beginning of year	$ 22,412	$ 19,185	$ 13,383
Increase related to tax positions taken during year	2,617	3,354	5,043
Increase/(decrease) related to tax positions taken in the prior year	259		759
Increase/(decrease) related to tax positions taken in the prior year		(127)
Unrecognized tax benefits at end of year	$ 25,288	$ 22,412	$ 19,185

Organization and Description of Business (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accumulated deficit	$ 1,319,578	$ 1,241,908
Net loss attributable to common stockholders	77,670	208,726	$ 204,618
Cash and cash equivalents	183,049	226,316
Short-term investments	$ 49,385	$ 50,083

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

- Definition

Amount of accumulated undistributed earnings (deficit).

+ References + Details

Revenues

12 Months Ended

Sep. 30, 2025

Revenue from Contract with Customer [Abstract]

Revenues

The Company’s revenue is generated through the sale of synthetic biology tools, such as synthetic genes, oligo pools, NGS tools, DNA libraries and biopharma services for antibody discovery, optimization and development ("Biopharma").

Contract Balances

The following table summarizes our contract balances:


	September 30,
(in thousands)	2025		2024
Contract assets(1)	$	3,857	$	2,031
Contract liabilities(2)	6,884		2,131

(1) Consists of unbilled amounts primarily related to Biopharma contracts which consists of research and development agreements with third parties.

(2) Consists of receipt of advance payments before our performance obligations related to revenue contracts are met.

Contracts with customers are in the written form of a purchase order or a quotation, which outline the promised goods and the agreed upon price. Such orders may be accompanied by a Master Supply or Distribution Agreement that establishes the terms and conditions, rights of the parties, delivery terms, and pricing. The

Company assesses collectability based on a number of factors, including past transaction history and creditworthiness of the customer.

Synthetic Genes, Oligo Pools, NGS Tools, and DNA Libraries

The Company recognizes revenue when control of the products is transferred to the customer and at a transaction price that is determined based on the agreed upon rates in the applicable order or master supply agreement applied to the quantity of synthetic DNA that was manufactured and shipped to the customer. The transaction price is determined based on the agreed upon rates in the quotation, the purchase order, or the master supply agreements applied to the quantity of all the products that were manufactured and shipped to the customer. The Company’s contracts may include one or more ordered products, and the shipment of these products comprises the performance obligation (s) under the contract. Accordingly, all of the transaction price, net of any discounts, is allocated to the performance obligation (s). The Company’s sales are primarily subject to Ex Works (as defined in Incoterms 2010) delivery terms and revenue, other than Biopharma revenue, is predominantly recorded at the point in time when products are picked up by the customer’s freight forwarder, as the Company has determined that this is the point in time that control transfers to the customer. The Company’s shipping and handling activities are considered a fulfillment cost. Shipping and handling fees charged to our customers are recognized as product revenue in the period shipped and the related costs for providing these services are recorded as a cost of revenue. The Company has elected to exclude all sales and value added taxes from the measurement of the transaction price. The Company has not adjusted the transaction price for significant financing since the time period between the transfer of goods and payment is less than one year. The Company has elected the practical expedient to not disclose the consideration allocated to remaining performance obligations and an explanation of when those amounts are expected to be recognized as revenue since the duration of the contracts is less than one year.

Biopharma

The Company’s Biopharma revenue primarily consists of research and development agreements with third parties that provide for up-front and milestone-based payments. The Company also enters into research and development agreements that do not include up-front or milestone-based payments and recognizes revenue on these types of agreements based on the timing of development activities. The Company’s research and development agreements may include more than one performance obligation. At the inception of the agreement, the Company assesses whether each obligation represents a separate performance obligation or whether such obligations should be combined as a single performance obligation. The transaction price for each agreement is determined based on the amount of consideration the Company expects to be entitled to for satisfying all performance obligations within the agreement. The Company assesses the nature of each performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue. In agreements where the Company satisfies performance obligation(s) over time, the Company recognizes development revenue typically using an input method based on costs incurred relative to the total expected cost which determines the extent of progress toward completion. As part of the accounting for these arrangements, the Company must develop estimates and assumptions that require judgment to determine the transaction price and progress towards completion. The Company reviews its estimate of the transaction price and progress toward completion based on the best information available to recognize the cumulative progress toward completion as of the end of each reporting period and makes revisions to such estimates as necessary. Also, these research and development agreements may include license payments. The Company recognizes revenue from functional license agreements when the license is transferred to the customer and the customer is able to use and benefit from the license. A functional license has significant standalone functionality because it can be used as is for performing a specific task.

For the years ended September 30, 2025, 2024 and 2023 the Company recognized revenue of $1.4 million, $1.7 million and $2.8 million, respectively, from the amount that was included in the contract liability balance at the beginning of each year.

In addition, for all periods presented, there was no revenue recognized in a reporting period from performance obligations satisfied in previous periods. The aggregate amount of the transaction price allocated to the performance obligations that are unsatisfied as of September 30, 2025 was $15.1 million. The Company expects to recognize revenue over the next twelve months relating to performance obligations unsatisfied as of September 30, 2025.

Based on the nature of the Company’s contracts with customers which are recognized over a term of less than 12 months, the Company has elected to use the practical expedient whereby costs to obtain a contract are

expensed as they are incurred. The Company states its revenues net of any taxes collected from customers that are required to be remitted to various government agencies. The amount of taxes collected from customers and payable to governmental entities is included on the balance sheet as part of “Accrued expenses and other current liabilities.”

Disaggregation of Revenues

The table below sets forth revenues by geographic region, based on ship-to destinations. Americas consists of the United States, Canada, Mexico and South America; EMEA consists of Europe, the Middle East, and Africa; and APAC primarily consists of Japan, China, South Korea, India, Singapore, Malaysia and Australia.


	Year ended September 30,
(in thousands)	2025		2024		2023
Americas	$	225,580	$	193,884	$	151,263
EMEA	124,240		92,567		71,389
APAC	26,752		26,523		22,457
Total	$	376,572	$	312,974	$	245,109

The table below sets forth revenues by products.


	Year ended September 30,
(in thousands)	2025		2024		2023
Synthetic genes	$	113,602	$	92,679	$	73,541
Oligo pools	20,230		16,906		14,489
DNA libraries	11,184		13,933		10,201
Antibody discovery	23,452		20,328		23,172
NGS tools	208,104		169,128		123,706
Total	$	376,572	$	312,974	$	245,109

The table below sets forth revenues by industry.


	Year ended September 30,
(in thousands)	2025		2024		2023
Industrial chemicals/materials	$	93,246	$	83,472	$	59,321
Academic research	65,861		58,452		45,847
Healthcare	215,092		168,959		137,148
Food/agriculture	2,373		2,091		2,793
Total revenues	$	376,572	$	312,974	$	245,109

Revenue from the United States represented 58%, 60% and 60% of the total revenue for the years ended September 30, 2025, 2024 and 2023, respectively.

Customer Concentration

There are no major customers who accounted for 10% or more of the Company’s revenue for the fiscal year ended September 30, 2025, September 30, 2024 and September 30, 2023.

There was one major customer who accounted for 10% or more of the net accounts receivable as of September 30, 2025. There were no major customers who accounted for 10% or more of the net accounts receivable as of September 30, 2024.

- Definition

The entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 7
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479806/606-10-50-7

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 9
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479806/606-10-50-9

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 10
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479806/606-10-50-10

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 15
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479806/606-10-50-15

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479806/606-10-50-12

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479806/606-10-50-12

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147479806/606-10-50-12

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
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-Subparagraph (e)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479806/606-10-50-12

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)(2)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479806/606-10-50-13

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Name Accounting Standards Codification
-Topic 606
-Publisher FASB
-URI https://asc.fasb.org/606/tableOfContent

+ Details

Consolidated Statements of Cash Flows (Parenthetical) - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Accounts receivable, net

^[1]

$ (22,382)

$ 8,444

$ (4,320)

Prepaid expenses and other current assets

^[2]

(3,717)

382

(4,166)

Other liabilities

^[3]

6,612

(2,317)

(108)

Related Party

Accounts receivable, net

(800)

1,200

(1,700)

Prepaid expenses and other current assets

(300)

Other liabilities

$ 200

$ 0

[1]	Including changes in the related parties' balances of $(0.8) million, $1.2 million and $(1.7) million for the years ended September 30, 2025, 2024 and 2023, respectively.
[2]	Including changes in a related party balances of $(0.3) million, $— million and $— million for the years ended September 30, 2025, 2024 and 2023, respectively.
[3]	Including changes in a related party' balances of $0.2 million, $— million and $— million for the years ended September 30, 2025, 2024 and 2023, respectively.

Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Income Tax Disclosure [Abstract]
Net operating loss carryforwards	$ 232,380	$ 226,959
Research and development credit carryforwards	67,626	59,578
Capitalized research and development	54,438	43,232
Operating lease liability	18,657	21,377
Stock-based compensation	13,359	13,384
Other	12,333	14,310
Gross deferred tax assets	398,793	378,840
Less: Valuation allowance	(383,378)	(360,594)
Net deferred tax assets	15,415	18,246
Operating lease right-of-use asset	(12,174)	(14,786)
Intangible assets	(3,241)	(3,460)
Gross deferred tax liabilities	(15,415)	(18,246)
Total net deferred tax asset	$ 0	$ 0

Income Taxes

12 Months Ended

Sep. 30, 2025

Income Tax Disclosure [Abstract]

Income Taxes

The Company recorded income tax expense of $0.7 million, $0.6 million and $1.2 million for the years ended September 30, 2025, 2024 and 2023, respectively.

The domestic and foreign components of pre-tax loss for the years ended September 30, 2025, 2024, and 2023 are as follows:


	Year ended September 30,
(in thousands)	2025		2024		2023
US	$	(78,490)	$	(209,545)	$	(205,389)
Foreign	1,539		1,379		1,923
Total	$	(76,951)	$	(208,166)	$	(203,466)

The components of the income tax expense for the years ended September 30, 2025, 2024, and 2023 are as follows:


	Year ended September 30,
(in thousands)	2025		2024		2023
Current
Federal	$	—	$	—	$	—
State	27		20		9
Foreign	692		540		1,143
Total current	$	719	$	560	$	1,152

Deferred
Federal	$	—	$	—	$	—
State	—		—		—
Foreign	—		—		—
Total deferred	$	—	$	—	$	—

Total provision (benefit)	$	719	$	560	$	1,152

The following is a reconciliation of the statutory federal income tax rate to the Company’s effective tax rate for the years ended September 30, 2025, 2024, and 2023:


	Year ended September 30,
	2025		2024		2023
Tax expense computed at the federal statutory rate	21	%	21	%	21	%
Change in valuation allowance	(22)	%	(22)	%	(25)	%
Research and development credit benefit	7	%	3	%	5	%
Section 162(m) limitation on compensation	(9)	%	(1)	%	—	%
Stock-based compensation	1	%	(1)	%	(1)	%
Change in fair value of contingent consideration and holdbacks	—	%	—	%	1	%
Gain on sale of intangible assets	1	%	—	%	—	%
Others	—	%	—	%	(2)	%
Total income tax expense	(1)	%	—	%	(1)	%

The significant components of the Company’s deferred tax assets and liabilities are as follows for the years ended September 30, 2025, and 2024:


	September 30,
(in thousands)	2025		2024
Net operating loss carryforwards	$	232,380	$	226,959
Research and development credit carryforwards	67,626		59,578
Capitalized research and development	54,438		43,232
Operating lease liability	18,657		21,377
Stock-based compensation	13,359		13,384
Other	12,333		14,310
Gross deferred tax assets	$	398,793	$	378,840
Less: Valuation allowance	(383,378)		(360,594)
Net deferred tax assets	$	15,415	$	18,246
Operating lease right-of-use asset	$	(12,174)	$	(14,786)
Intangible assets	(3,241)		(3,460)
Gross deferred tax liabilities	$	(15,415)	$	(18,246)
Total net deferred tax asset	$	—	$	—

Based on the available evidence, management believes it is more likely than not that the deferred tax assets will not be fully realizable. Accordingly, the Company has provided a full valuation allowance against its deferred tax assets at September 30, 2025 and 2024. The valuation allowance was $383.4 million and $360.6 million as of September 30, 2025 and 2024, respectively. The change in the valuation allowance was mainly due to an increase in the current year net operating loss, research and development credits and capitalized research and development during the fiscal year 2025.

The Company intends to continue maintaining a full valuation allowance on the Company’s deferred tax assets until there is sufficient evidence to support the reversal of all or some portion of the allowance. The release of all, or a portion, of the valuation allowance would result in the recognition of certain deferred tax assets and a decrease to income tax expense for the period the release is recorded.

As of September 30, 2025, the Company had net operating loss carryforwards of approximately $915.6 million and $621.2 million available to reduce future taxable income, if any, for federal and state income tax purposes, respectively. Of the total federal net operating loss carryforwards, $714.8 million never expires and the remaining carryforwards of $200.8 million expire at various dates beginning in 2032 through 2038. Of the total state net operating loss carryforwards, the California State tax loss carryforwards of $310.0 million begin to expire in 2033 and the remaining carryforwards of $311.2 million for other states begin to expire at various dates beginning 2026 and beyond.

The Company also had federal and state research and development credit carryforwards of approximately $58.1 million and $38.8 million, respectively, at September 30, 2025. The federal credits will expire starting in 2033 if not utilized. The California research and development credits have no expiration date. Utilization of the net operating losses and tax credits is subject to annual limitation due to the ownership change limitations provided by the Internal Revenue Code and similar state provisions. Such annual limitations may result in the expiration of the net operating losses and tax credits before utilization.

The provisions of ASC 740-10, Accounting for Uncertainty in Income Taxes, prescribe a comprehensive model for the recognition, measurement, and presentation and disclosure in financial statements of any uncertain tax positions that have been taken or expected to be taken on a tax return. The Company has identified uncertain tax positions related to federal and state research and development credits and foreign jurisdictions.

The aggregate changes in the balance of gross unrecognized tax benefits are as follows:


	Federal and state
	September 30,
(in thousands)	2025		2024		2023
Unrecognized tax benefits at beginning of year	$	22,412	$	19,185	$	13,383
Increase related to tax positions taken during year	2,617		3,354		5,043
Increase/(decrease) related to tax positions taken in the prior year	259		(127)		759
Unrecognized tax benefits at end of year	$	25,288	$	22,412	$	19,185

The Company does not expect a material change in unrecognized tax benefits in the next twelve months. As of September 30, 2025 and 2024, approximately $0.6 million and $0.4 million of unrecognized tax benefit would, if recognized, impact the Company’s effective income tax rate, respectively.

It is the Company’s policy to include penalties and interest expense related to income taxes as a component of other expense and interest expense, respectively, as necessary. The Company’s management determined that no accrual for interest and penalties was required as of September 30, 2025 and 2024.

The Company’s files federal and state income tax returns with varying statutes of limitations. All tax years remain open to examination due to the carryover of net operating losses or tax credits. The Company currently has no federal, state or foreign tax examinations in progress.

In fiscal year 2022, the Company began recognizing an additional component of total Federal tax expense, the tax on Global Intangible Low-Taxed Income (“GILTI”) provision of the Tax Act, which became applicable to the Company in fiscal year 2022. The Company elected to account for GILTI as a period cost, and therefore included GILTI expense in the effective tax rate calculation. This provision did not have a material effect on the effective tax rate for the years ended September 30, 2025, 2024 and 2023.

On July 4, 2025, H.R.1, commonly referred to as the One Big Beautiful Bill Act, was enacted in the U.S., which includes a broad range of tax reform provisions, including extending and modifying certain key Tax Cuts and Jobs Act provisions (both domestic and international). The legislation has multiple effective dates, with certain provisions effective in 2025 and others to be implemented through 2027. The Company has evaluated the impact of the guidance provided to date and determined that it did not have a material impact related to fiscal year ended September 30, 2025. The Company will continue to evaluate the impact of changes to various provisions that could affect our income tax payable and deferred tax liability.

- Definition

The entire disclosure for income tax.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 942
-SubTopic 740
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
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-URI https://asc.fasb.org/1943274/2147477617/942-740-50-1

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
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-Name Accounting Standards Codification
-Section S50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480738/235-10-S50-1

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 1
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478822/944-740-50-1

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147482685/740-10-50-12

Reference 5: http://www.xbrl.org/2003/role/exampleRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
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-Paragraph 1
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/740/tableOfContent

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
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-Section 50
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-URI https://asc.fasb.org/1943274/2147482685/740-10-50-14

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482685/740-10-50-21

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
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-Section 50
-Paragraph 17
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482685/740-10-50-17

Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
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-Name Accounting Standards Codification
-Section S99
-Paragraph 2
-Subparagraph (SAB Topic 11.C)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479360/740-10-S99-2

Reference 17: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482603/740-30-50-2

+ Details

Segment Information (Tables)

12 Months Ended

Sep. 30, 2025

Segment Reporting [Abstract]

Summary of Segment Reporting Information, by Segment

The following table presents entity-wide significant expense categories and net loss details provided to the CODM:


	Year ended September 30,
(In thousands)	2025		2024		2023
Revenues	$	376,572	$	312,974	$	245,109
Costs and expenses:
Cost of revenues[1]	$	161,545	$	154,030	$	132,417
Research and development expenses[1]	69,950		76,605		88,937
Selling, general and administrative expenses[1]	192,024		175,883		171,070
Depreciation and amortization	24,853		31,432		29,310
Stock-based compensation expense	64,459		50,925		30,278
Restructuring and other costs	—		—		9,384
Change in fair value of contingent considerations and holdbacks	—		—		(5,913)
Impairment of long-lived assets	—		44,930		6,785
Total costs and expenses	$	512,831	$	533,805	$	462,268
Loss from operations	$	(136,259)	$	(220,831)	$	(217,159)
Gain on sale of business	$	48,847	$	—	$	—
Interest income	11,364		15,344		14,365
Other income (expense), net	(903)		(2,679)		(672)
Income (loss) before income taxes	$	(76,951)	$	(208,166)	$	(203,466)
Income tax expense	(719)		(560)		(1,152)
Net loss	$	(77,670)	$	(208,726)	$	(204,618)

[1] Excludes depreciation and amortization and stock-based compensation expense

Summary of Significant Accounting Policies - Narrative (Details) $ in Millions	12 Months Ended
	Sep. 30, 2025 USD ($) segment	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Accrued expenses	$ 1.2	$ 1.1
Credit period granted to customers	30 days
Number of reportable segments \| segment	1
Number of operating segments \| segment	1
Advertising and promotion expenses	$ 7.0	5.2	$ 2.9
Equity Method Investments
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Investment in equity securities		$ 1.5

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Income Taxes - Narrative (Details) - USD ($) $ in Thousands	12 Months Ended
Income Taxes - Narrative (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Income Tax Contingency [Line Items]
Income tax expense (benefit)	$ 719	$ 560	$ 1,152
Valuation allowance	383,378	360,594
Impact of unrecognized tax benefits on income tax rate if recognized	600	400
Domestic Tax Jurisdiction
Income Tax Contingency [Line Items]
Operating loss carry forwards	915,600	621,200
Domestic Tax Jurisdiction \| Never Expire
Income Tax Contingency [Line Items]
Operating loss carry forwards	714,800
Domestic Tax Jurisdiction \| 2032 through 2038
Income Tax Contingency [Line Items]
Operating loss carry forwards	200,800
State and Local Jurisdiction
Income Tax Contingency [Line Items]
Operating loss carry forwards	915,600	$ 621,200
State and Local Jurisdiction \| 2025
Income Tax Contingency [Line Items]
Operating loss carry forwards	310,000
State and Local Jurisdiction \| 2025 and Beyond
Income Tax Contingency [Line Items]
Operating loss carry forwards	311,200
Research Tax Credit Carryforward \| Domestic Tax Jurisdiction
Income Tax Contingency [Line Items]
Tax credit carry forwards	58,100
Research Tax Credit Carryforward \| State and Local Jurisdiction
Income Tax Contingency [Line Items]
Tax credit carry forwards	$ 38,800

Consolidated Statements of Stockholders’ Equity - USD ($) $ in Thousands	Total	Cumulative Effect, Period of Adoption, Adjustment	Common stock	Additional paid-in capital	Accumulated other comprehensive income / (loss)	Accumulated deficit	Accumulated deficit Cumulative Effect, Period of Adoption, Adjustment
Beginning balance (in shares) at Sep. 30, 2022			56,523,000
Beginning balance at Sep. 30, 2022	$ 789,385		$ 0	$ 1,619,644	$ (1,843)	$ (828,416)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)			648,000
Issuance of shares under the employee stock purchase plan (in shares)			217,000
Issuance of shares under the employee stock purchase plan	3,937			3,937
Exercise of stock options (in shares)			118,000
Exercise of stock options	1,379			1,379
Business acquisition (in shares)			277,000
Business acquisition	5,860			5,860
Stock-based compensation expense	30,821			30,821
Other comprehensive income (loss)	1,087				1,087
Repurchases of common stock for income tax withholding (in shares)			(226,000)
Repurchase of common stock for income tax withholdings	(4,419)			(4,419)
Net loss	(204,618)					(204,618)
Ending balance (in shares) at Sep. 30, 2023			57,557,000
Ending balance at Sep. 30, 2023	$ 623,432	$ (148)	$ 0	1,657,222	(756)	(1,033,034)	$ (148)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Accounting standards update	Accounting Standards Update 2016-13 [Member]
Vesting of restricted stock units (in shares)			896,000
Issuance of shares under the employee stock purchase plan (in shares)			177,000
Issuance of shares under the employee stock purchase plan	$ 3,765			3,765
Exercise of stock options (in shares)			384,000
Exercise of stock options	7,100			7,100
Stock-based compensation expense	51,007			51,007
Other comprehensive income (loss)	234				234
Repurchases of common stock for income tax withholding (in shares)			(137,000)
Repurchase of common stock for income tax withholdings	(3,975)			(3,975)
Net loss	$ (208,726)					(208,726)
Ending balance (in shares) at Sep. 30, 2024	58,877,000		58,877,000
Ending balance at Sep. 30, 2024	$ 472,689		$ 0	1,715,119	(522)	(1,241,908)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)			1,260,000
Restricted common stock canceled (in shares)			(137,000)
Issuance of shares under the employee stock purchase plan (in shares)	144,000		144,000
Issuance of shares under the employee stock purchase plan	$ 4,213			4,213
Exercise of stock options (in shares)	484,000		488,000
Exercise of stock options	$ 9,343			9,343
Stock-based compensation expense	64,504			64,504
Other comprehensive income (loss)	(105)				(105)
Repurchase of common stock for income tax withholdings	(16)			(16)
Net loss	$ (77,670)					(77,670)
Ending balance (in shares) at Sep. 30, 2025	60,631,000		60,632,000
Ending balance at Sep. 30, 2025	$ 472,958		$ 0	$ 1,793,163	$ (627)	$ (1,319,578)

Cybersecurity Risk Management and Strategy Disclosure	12 Months Ended
Cybersecurity Risk Management and Strategy Disclosure	Sep. 30, 2025
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]	We have implemented and maintain various information security processes designed to identify, assess and manage material risks from cybersecurity threats to our critical computer networks, third-party hosted services, communications systems, hardware and software, and our critical data, including, among other things, intellectual property, trade secrets, confidential information that is proprietary, strategic or competitive in nature, and personal data. Our Chief Information Officer (“CIO”) together with our Senior Director of IT Infrastructure, Security and Compliance and other members of the Information and Business Technology (“IBT”) Security team, are responsible for establishing and implementing cybersecurity policies and procedures, which includes developing and updating our Security Incident Response Policy (“IRP”), managing incident response, and overseeing any policy exceptions and potential compensating controls. Our cybersecurity program is based on the ISO 27001 security controls. We maintain an ISO 27001:2022 certification and we undergo routine audits by an independent, certified accreditation body to maintain this certification. We also provide annual, mandatory cybersecurity training for employees to equip our workforce with the knowledge to identify and respond to cybersecurity threats, such as phishing attempts. Our process for assessing, identifying, and managing material risks from cybersecurity threats is integrated into our overall enterprise risk management process. As part of our overall enterprise risk management process, we have a cybersecurity risk management strategy based on National Institute of Standards and Technology (NIST) Special Publication. 800-30 “Guide for Conducting Risk Assessments” that provide guidelines and principles for information technology security risk management.
Cybersecurity Risk Management Processes Integrated [Flag]	true
Cybersecurity Risk Management Processes Integrated [Text Block]	Our process for assessing, identifying, and managing material risks from cybersecurity threats is integrated into our overall enterprise risk management process. As part of our overall enterprise risk management process, we have a cybersecurity risk management strategy based on National Institute of Standards and Technology (NIST) Special Publication. 800-30 “Guide for Conducting Risk Assessments” that provide guidelines and principles for information technology security risk management.
Cybersecurity Risk Management Third Party Engaged [Flag]	true
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]	true
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]	false
Cybersecurity Risk Board of Directors Oversight [Text Block]	The Board oversees management’s processes for identifying and mitigating risks, including cybersecurity risks, to help align our risk exposure with our strategic objectives. Our CIO regularly briefs the Board on cybersecurity matters. We have procedures led by our CIO which govern our assessment, response and notification of internal and external parties upon the occurrence of a cybersecurity incident. Depending on the nature and severity of an incident, this process provides for escalating notification to our executive team, to evaluate the overall impact and appropriate or required external notifications. Based on its nature and severity, the Board would be informed of an incident by our executive team.
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]	The Board oversees management’s processes for identifying and mitigating risks, including cybersecurity risks, to help align our risk exposure with our strategic objectives.
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]	Our CIO regularly briefs the Board on cybersecurity matters. We have procedures led by our CIO which govern our assessment, response and notification of internal and external parties upon the occurrence of a cybersecurity incident.
Cybersecurity Risk Role of Management [Text Block]	Under the IRP, cybersecurity incidents are escalated based on a defined incident severity to management as appropriate. Management, including the CIO, is involved in assessing and managing our cybersecurity risks. Our CIO has 14 years of experience managing information technology in complex environments. As noted above, the company’s IRP includes standard processes for escalating significant cybersecurity incidents to management, including the CIO, who then informs the Board based on the nature and severity of the incident. The company’s incident response team also coordinates with external legal advisors, cybersecurity forensic firms, communication specialists, and other outside advisors and experts, as appropriate.
Cybersecurity Risk Management Positions or Committees Responsible [Flag]	true
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]	Under the IRP, cybersecurity incidents are escalated based on a defined incident severity to management as appropriate. Management, including the CIO, is involved in assessing and managing our cybersecurity risks. Our CIO has 14 years of experience managing information technology in complex environments. As noted above, the company’s IRP includes standard processes for escalating significant cybersecurity incidents to management, including the CIO, who then informs the Board based on the nature and severity of the incident.
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]	Our CIO has 14 years of experience managing information technology in complex environments. As noted above, the company’s IRP includes standard processes for escalating significant cybersecurity incidents to management, including the CIO, who then informs the Board based on the nature and severity of the incident.
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]	As noted above, the company’s IRP includes standard processes for escalating significant cybersecurity incidents to management, including the CIO, who then informs the Board based on the nature and severity of the incident. The company’s incident response team also coordinates with external legal advisors, cybersecurity forensic firms, communication specialists, and other outside advisors and experts, as appropriate.
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]	true

Balance Sheet Components - Inventory (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Balance Sheet Related Disclosures [Abstract]
Raw Materials	$ 20,191	$ 17,316
Work-in-process	2,265	2,146
Finished Goods	5,853	4,616
Total inventories	$ 28,309	$ 24,078

Investment in Equity Securities - Fair Value of Investment (Details)	May 02, 2025
Discount for lack of marketability
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Equity securities, measurement input	0.100
Risk-free interest rate
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Equity securities, measurement input	0.038
Time of exit
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Equity securities, measurement input	3
Volatility
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Equity securities, measurement input	0.765

Related Party Transactions	12 Months Ended
Related Party Transactions	Sep. 30, 2025
Related Party Transactions [Abstract]
Related Party Transactions	Related Party Transactions During the years ended September 30, 2025, 2024 and 2023, the Company purchased raw materials from related parties in the amount of $— million, $4.4 million and $6.8 million, respectively. During the years ended September 30, 2025, 2024 and 2023, the Company recognized revenues from the related parties in the amount of $12.2 million, $12.1 million and $5.9 million, respectively. Payable balances with the related parties were immaterial as of September 30, 2025 and 2024. Receivable balances with the related parties were $1.3 million and $0.5 million as of September 30, 2025 and 2024, respectively. Subsequent to the investment in Atlas, the Company concluded that Atlas is a related party. The following are the transactions with Atlas: During the years ended September 30, 2025, the Company recognized less than $0.1 million revenue from the Atlas. During the year ended September 30, 2025, the Company received sublease income accounted for as other income in the amount of $1.1 million. As of September 30, 2025 investment in Atlas included in the investment in equity securities was $53.9 million (see note 6). As of September 30, 2025 other receivable balance primarily related to sublease income (see note 6) included in prepaid and other current assets was $0.3 million. As of September 30, 2025, the carrying value of the promissory note receivable included in other non-current assets was $1.8 million. The Company recognized immaterial amount of interest income during the year ended September 30, 2025. As of September 30, 2025 sublease security deposit balance included in other non-current liabilities was $0.2 million.

- Definition

The entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 850
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483326/850-10-50-1

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480990/946-20-50-2

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480990/946-20-50-5

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480990/946-20-50-6

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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-Section 50
-Paragraph 6
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483326/850-10-50-6

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 850
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483326/850-10-50-1

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 850
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483326/850-10-50-1

+ Details

Investment in Equity Securities - Narrative (Details)		12 Months Ended
Investment in Equity Securities - Narrative (Details)	May 02, 2025 USD ($)	Sep. 30, 2025 USD ($)	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Promissory note receivable received as consideration for sale of business		$ 1,696,000	$ 0	$ 0
Equity interest accounted for the investment at fair value		53,890,000	0	0
Promissory note receivable, annual interest percentage	0.04
Gain on sale of business		48,847,000	0	$ 0
Variable interest entity, primary beneficiary, maximum loss exposure, amount		56,000,000
Variable interest entity impairments		0
Fair value, measurement with unobservable inputs reconciliation, recurring basis, liability value		400,000
Equity securities without readily determinable fair value, impairment loss, annual amount		1,100,000	$ 2,200,000
Disposal Group, Disposed of by Sale, Not Discontinued Operations \| DNA Digital Data Storage
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Fair value of promissory note receivable		1,700,000
Carrying value of promissory note receivable		1,800,000
Atlas Data Storage, Inc \| Disposal Group, Disposed of by Sale, Not Discontinued Operations \| DNA Digital Data Storage
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Collaborative arrangement, consideration transferred	$ 73,000,000
Upfront cash consideration	2,500,000
Promissory note receivable received as consideration for sale of business	2,000,000
Contribution agreement, contingent manufacturing and commercial milestone payments	75,000,000
Equity interest accounted for the investment at fair value	53,890,000
Fair value of promissory note receivable	1,696,000
Gain on sale of business	$ 48,847,000	$ 48,800,000

Balance Sheet Components (Tables)

12 Months Ended

Sep. 30, 2025

Balance Sheet Related Disclosures [Abstract]

Summary of inventories

Inventories consist of the following:


	September 30,
(in thousands)	2025		2024
Raw Materials	$	20,191	$	17,316
Work-in-process	2,265		2,146
Finished Goods	5,853		4,616
	$	28,309	$	24,078

Summary of Property Plant And Equipment

Property and equipment, net consists of the following:


	September 30,
(in thousands)	2025		2024
Laboratory equipment	$	101,583	$	99,528
Furniture, fixtures and other equipment	2,905		2,944
Vehicles	211		211
Computer equipment	3,176		3,249
Computer software	11,009		10,095
Leasehold improvements	58,277		57,448
Construction in progress	20,116		4,688
	$	197,277	$	178,163
Less: Accumulated depreciation and amortization	(94,994)		(75,643)
	$	102,283	$	102,520

Summary of Other Current Liabilities

Other current liabilities consist of the following:


	September 30,
(in thousands)	2025		2024
Income and other taxes payable	$	4,543	$	2,725
Contract liabilities	6,884		2,131
Other current liabilities	722		961
	$	12,149	$	5,817

Balance Sheet Components - Property Plant and Equipment (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 197,277	$ 178,163
Less: Accumulated depreciation and amortization	(94,994)	(75,643)
Property and equipment, net	102,283	102,520
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	101,583	99,528
Furniture, fixtures and other equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	2,905	2,944
Vehicles
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	211	211
Computer equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	3,176	3,249
Computer software
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	11,009	10,095
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	58,277	57,448
Construction in progress
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 20,116	$ 4,688

Goodwill and Intangible Assets - Finite Lived Intangible Assets Future Amortization Expense (Details) - USD ($) $ in Thousands	Sep. 30, 2025	Sep. 30, 2024
Goodwill and Intangible Assets Disclosure [Abstract]
2026	$ 1,053
2027	1,053
2028	1,053
2029	1,053
2030	1,053
Thereafter	8,160
Net book value	$ 13,425	$ 14,478

Fair Value Measurement (Tables)

12 Months Ended

Sep. 30, 2025

Fair Value Disclosures [Abstract]

Summary of Company's Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis

As of September 30, 2025, financial assets measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	150,372	$	—	$	—	$	150,372
U.S. government treasury bills	49,385		—		—		49,385
Total financial assets	$	199,757	$	—	$	—	$	199,757

As of September 30, 2024, financial assets measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	199,858	$	—	$	—	$	199,858
U.S. government treasury bills	50,083		—		—		50,083
Total financial assets	$	249,941	$	—	$	—	$	249,941

Leases - Supplemental Cash Flow Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
Leases [Abstract]
Cash payments included in the measurement of operating lease liabilities	$ 14,853	$ 14,707

Income Taxes - Effective Income Tax Rate Reconciliation (Details)	12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2023
Income Tax Disclosure [Abstract]
Tax expense computed at the federal statutory rate	21.00%	21.00%	21.00%
Change in valuation allowance	(22.00%)	(22.00%)	(25.00%)
Research and development credit benefit	7.00%	3.00%	5.00%
Section 162(m) limitation on compensation	(9.00%)	(1.00%)	0.00%
Stock-based compensation	1.00%	(1.00%)	(1.00%)
Change in fair value of contingent consideration and holdbacks	0.00%	0.00%	1.00%
Gain on sale of intangible assets	1.00%	0.00%	0.00%
Others	0.00%	0.00%	(2.00%)
Total income tax expense	(1.00%)	0.00%	(1.00%)

Revenues - Revenues by Products (Details) - USD ($)
$ in Thousands

12 Months Ended

Sep. 30, 2025

Sep. 30, 2024

Sep. 30, 2023

Segment Reporting Information [Line Items]

Revenues

^[1]

$ 376,572

$ 312,974

$ 245,109

Synthetic genes

Segment Reporting Information [Line Items]

Revenues

113,602

92,679

73,541

Oligo pools

Segment Reporting Information [Line Items]

Revenues

20,230

16,906

14,489

DNA libraries

Segment Reporting Information [Line Items]

Revenues

11,184

13,933

10,201

Antibody discovery

Segment Reporting Information [Line Items]

Revenues

23,452

20,328

23,172

NGS tools

Segment Reporting Information [Line Items]

Revenues

$ 208,104

$ 169,128

$ 123,706

[1]	Including revenues from related parties of $12.2 million, $12.1 million and $5.9 million during the year end September 30, 2025, 2024 and 2023, respectively.

- Definition

+ References

+ Details

Revenues (Tables)

12 Months Ended

Sep. 30, 2025

Revenue from Contract with Customer [Abstract]

Summary of Contract Balances

The following table summarizes our contract balances:


	September 30,
(in thousands)	2025		2024
Contract assets(1)	$	3,857	$	2,031
Contract liabilities(2)	6,884		2,131

(1) Consists of unbilled amounts primarily related to Biopharma contracts which consists of research and development agreements with third parties.

(2) Consists of receipt of advance payments before our performance obligations related to revenue contracts are met.

Summary of Revenue by Geographic Region


	Year ended September 30,
(in thousands)	2025		2024		2023
Americas	$	225,580	$	193,884	$	151,263
EMEA	124,240		92,567		71,389
APAC	26,752		26,523		22,457
Total	$	376,572	$	312,974	$	245,109

Summary of Revenue by Product

The table below sets forth revenues by products.


	Year ended September 30,
(in thousands)	2025		2024		2023
Synthetic genes	$	113,602	$	92,679	$	73,541
Oligo pools	20,230		16,906		14,489
DNA libraries	11,184		13,933		10,201
Antibody discovery	23,452		20,328		23,172
NGS tools	208,104		169,128		123,706
Total	$	376,572	$	312,974	$	245,109

Summary of Revenue by Industry

The table below sets forth revenues by industry.


	Year ended September 30,
(in thousands)	2025		2024		2023
Industrial chemicals/materials	$	93,246	$	83,472	$	59,321
Academic research	65,861		58,452		45,847
Healthcare	215,092		168,959		137,148
Food/agriculture	2,373		2,091		2,793
Total revenues	$	376,572	$	312,974	$	245,109

Impairment of Long-lived Assets (Tables)

12 Months Ended

Sep. 30, 2025

Restructuring and Related Activities [Abstract]

Summary of Details of Impairment of Long-Lived Assets Held and Used

The impairment charges recorded for the year ended September 30, 2024 and September 30, 2023 are as follows:


	Year ended September 30,
(in thousands)	2024		2023
Property and equipment	$	9,066	$	6,785
Finite-lived intangible assets	35,864		—
Total	$	44,930	$	6,785