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<import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
<import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
<import namespace="http://fasb.org/us-gaap/2020-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/country/2020-01-31" schemaLocation="https://xbrl.sec.gov/country/2020/country-2020-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/currency/2020-01-31" schemaLocation="https://xbrl.sec.gov/currency/2020/currency-2020-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/exch/2020-01-31" schemaLocation="https://xbrl.sec.gov/exch/2020/exch-2020-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/naics/2017-01-31" schemaLocation="https://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/sic/2020-01-31" schemaLocation="https://xbrl.sec.gov/sic/2020/sic-2020-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/stpr/2018-01-31" schemaLocation="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd" />
<import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
<import namespace="http://xbrl.sec.gov/dei/2020-01-31" schemaLocation="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd" />
<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
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<import namespace="http://fasb.org/srt/2020-01-31" schemaLocation="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd" />
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<element name="UnderwritingDiscountsCommissionsAndOfferingExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_UnderwritingDiscountsCommissionsAndOfferingExpenses" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="PaymentsToRepurchasesOfCommonStockForTaxWithholding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_PaymentsToRepurchasesOfCommonStockForTaxWithholding" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IncreaseDecreaseInLitigationSettlement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_IncreaseDecreaseInLitigationSettlement" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="StockholdersEquityNoteWarrantsOrRightsDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_StockholdersEquityNoteWarrantsOrRightsDisclosureTextBlock" substitutionGroup="xbrli:item" />
<element name="BasisOfPresentationAndUseOfEstimatesPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_BasisOfPresentationAndUseOfEstimatesPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="SupplementalBalanceSheetInformationRelatingToCompaniesOperatingLeaseTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_SupplementalBalanceSheetInformationRelatingToCompaniesOperatingLeaseTableTextBlock" substitutionGroup="xbrli:item" />
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<element name="SubsequentPublicOffering1Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_SubsequentPublicOffering1Member" substitutionGroup="xbrli:item" />
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<element name="PurposeDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_PurposeDomain" substitutionGroup="xbrli:item" />
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<element name="GrantorDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_GrantorDomain" substitutionGroup="xbrli:item" />
<element name="FairValueOfAssetsAndLiabilitiesMeasuredOnNonRecurringBasisLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_FairValueOfAssetsAndLiabilitiesMeasuredOnNonRecurringBasisLineItems" substitutionGroup="xbrli:item" />
<element name="GoodwillAndIntangibleAssetsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_GoodwillAndIntangibleAssetsTable" substitutionGroup="xbrldt:hypercubeItem" />
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<element name="OperatingLeaseAnnualBaseRentPercentageIncrease" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_OperatingLeaseAnnualBaseRentPercentageIncrease" substitutionGroup="xbrli:item" />
<element name="WilsonvilleOregonMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_WilsonvilleOregonMember" substitutionGroup="xbrli:item" />
<element name="OperatingLeaseRenewalTermAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_OperatingLeaseRenewalTermAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="OperatingLeaseRenewalTermDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_OperatingLeaseRenewalTermDomain" substitutionGroup="xbrli:item" />
<element name="RenewalTermOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_RenewalTermOneMember" substitutionGroup="xbrli:item" />
<element name="RenewalTermTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_RenewalTermTwoMember" substitutionGroup="xbrli:item" />
<element name="WarrantsOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_WarrantsOneMember" substitutionGroup="xbrli:item" />
<element name="CommonStockIssuedForCashlessExercise" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_CommonStockIssuedForCashlessExercise" substitutionGroup="xbrli:item" />
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<element name="SaleOfStockAuthorizedAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="twst_SaleOfStockAuthorizedAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="TwoThousandAndEighteenEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_TwoThousandAndEighteenEmployeeStockPurchasePlanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandAndEighteenEquityIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_TwoThousandAndEighteenEquityIncentivePlanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandAndFifteenEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_TwoThousandAndFifteenEmployeeStockPurchasePlanMember" substitutionGroup="xbrli:item" />
<element name="RevisedAnnualEquityAwardProgrammeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_RevisedAnnualEquityAwardProgrammeMember" substitutionGroup="xbrli:item" />
<element name="CommonStockCapitalSharesReservedForFutureIssuanceAnnualAutomaticIncreasePercentage" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="twst_CommonStockCapitalSharesReservedForFutureIssuanceAnnualAutomaticIncreasePercentage" substitutionGroup="xbrli:item" />
<element name="MinimumIncreaseCommonStockCapitalSharesReservedForFutureIssuance" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="twst_MinimumIncreaseCommonStockCapitalSharesReservedForFutureIssuance" substitutionGroup="xbrli:item" />
<element name="PercentageOfPayrollDeductionOnEligibleCommonStock" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_PercentageOfPayrollDeductionOnEligibleCommonStock" substitutionGroup="xbrli:item" />
<element name="CommonStockSharesMayBeIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="twst_CommonStockSharesMayBeIssued" substitutionGroup="xbrli:item" />
<element name="ShareBasedCompensationByShareBasedPaymentArrangementInstrumentsOtherThanOptionsExpectedToVestOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="twst_ShareBasedCompensationByShareBasedPaymentArrangementInstrumentsOtherThanOptionsExpectedToVestOutstanding" substitutionGroup="xbrli:item" />
<element name="ExecutiveOfficersAndSeniorLevelEmployeesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_ExecutiveOfficersAndSeniorLevelEmployeesMember" substitutionGroup="xbrli:item" />
<element name="DisclosureOfEmployeeStockPurchasePlanTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_DisclosureOfEmployeeStockPurchasePlanTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="DisclosureofemployeestockpurchaseplanLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_DisclosureofemployeestockpurchaseplanLineItems" substitutionGroup="xbrli:item" />
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfOptionsAvailableForGrant" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfOptionsAvailableForGrant" substitutionGroup="xbrli:item" />
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantRestrictedStockUnitsForfeited" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantRestrictedStockUnitsForfeited" substitutionGroup="xbrli:item" />
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantRestrictedStockUnitsGrantedInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantRestrictedStockUnitsGrantedInPeriod" substitutionGroup="xbrli:item" />
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<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAvailableForGrantForfeited" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="twst_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAvailableForGrantForfeited" substitutionGroup="xbrli:item" />
<element name="NonvestedRestrictedStockUnitsActivityAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_NonvestedRestrictedStockUnitsActivityAbstract" substitutionGroup="xbrli:item" />
<element name="NonvestedRestrictedStockUnitsActivityTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_NonvestedRestrictedStockUnitsActivityTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="NonvestedRestrictedStockUnitsActivityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_NonvestedRestrictedStockUnitsActivityLineItems" substitutionGroup="xbrli:item" />
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestAggregateIntrinsicValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="twst_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestAggregateIntrinsicValue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
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<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestWeightedAverageGrantDateFairValue" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="twst_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestWeightedAverageGrantDateFairValue" substitutionGroup="xbrli:item" />
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<element name="WeightedAverageNumberBasicAndDilutedSharesOutstandingAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_WeightedAverageNumberBasicAndDilutedSharesOutstandingAbstract" substitutionGroup="xbrli:item" />
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<element name="OptionsToPurchaseCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_OptionsToPurchaseCommonStockMember" substitutionGroup="xbrli:item" />
<element name="RestrictedShareUnitsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_RestrictedShareUnitsMember" substitutionGroup="xbrli:item" />
<element name="WarrantsToPurchaseCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_WarrantsToPurchaseCommonStockMember" substitutionGroup="xbrli:item" />
<element name="StockOptionsBasedOnPerformanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_StockOptionsBasedOnPerformanceMember" substitutionGroup="xbrli:item" />
<element name="DnaAndBiopharmaLibrariesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_DnaAndBiopharmaLibrariesMember" substitutionGroup="xbrli:item" />
<element name="OligoPoolsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_OligoPoolsMember" substitutionGroup="xbrli:item" />
<element name="SyntheticGenesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="twst_SyntheticGenesMember" substitutionGroup="xbrli:item" />
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