Press Release Details
Twist Bioscience Launches Full Length Unique Dual Index Adapters to Enable PCR-free Whole Genome Sequencing
Adds to robust offering of NGS tools enabling exome sequencing, whole genome sequencing, RNA sequencing and methylation detection
Enables multiplexing and high throughput sequencing
New offering expands and complements Twist’s portfolio of universal adapters
Twist Full Length UDI Adapters to be highlighted at ASHG 2023
The new adapters include unique dual indexing (UDI) sequences, along with flow cell binding site and sequencing priming site, enabling NGS library preparation in a single ligation step and eliminating the need for PCR and amplification. This can streamline the library preparation workflow, reduce hands-on time, and also eliminate the sequence errors and artifacts potentially introduced during PCR amplification. The product comes with 1536 UDIs, which are barcoded indexes that allow for the tracking of individual samples. This is critical for researchers who multiplex, running tests on many samples at once to lower per-sample costs and increasing efficiency, such as core labs and scientists studying population genetics. Twist Full Length UDI Adapters enable researchers to track and run up to 1536 samples through a single sequencing run, while maintaining data integrity by identifying errors that occur from index hopping or well to well contamination prior to data analysis.
“As we grow our customer base, we are continuing to expand our offering to meet our customers’ needs, whether that is whole genome, exome or RNA sequencing,” said Emily M. Leproust, Ph.D., CEO and co-founder of
Twist Full Length Unique Dual Index Adapters
Twist Full Length UDI Adapters add to Twist’s portfolio of universal adapter systems, which include Twist Universal Adapter System and Twist High Throughput Universal Adapter System. Twist Full Length UDI Adapters include 1,536 indexes and come in automation-friendly configurations of 96 or 384 sets of adapters, giving customers the ability to multiplex anywhere between two and 1,536 samples. The full length UDI adapters can be used in various NGS workflows and for PCR-free whole genome sequencing.
Twist will have a booth at the
Twist will also present “Portfolio of RNA Sequencing Tools” in-booth on
Twist Bioscience Legal Notice Regarding Forward-Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical facts contained herein, including statements regarding the ability of Twist Full Length UDIs to enable PCR-free WGS and multiplexing at scale, are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements involve known and unknown risks, uncertainties, and other important factors that may cause Twist Bioscience’s actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the ability to achieve the expected benefits of Twist Bioscience’s workforce reduction and reduced investments in DNA data storage; the ability to attract new customers and retain and grow sales from existing customers; the ability of Twist to achieve sufficient revenue to achieve or maintain positive cash flow from operations or profitability in any given period; risks and uncertainties of rapidly changing technologies and extensive competition in synthetic biology that could make the products
SVP, Corporate Affairs